莳萝水提取物具有潜在的抗氧化和抗糖化作用。
Aqueous Extract of Anethum Graveolens L. has Potential Antioxidant and Antiglycation Effects.
作者信息
Oshaghi Ebrahim Abbasi, Khodadadi Iraj, Tavilani Heidar, Goodarzi Mohammad Taghi
机构信息
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Iran J Med Sci. 2016 Jul;41(4):328-33.
The aim of this study was to assess the antiglycation and antioxidant properties of aqueous extract of Anethum graveolens (dill). In the in vivo and in vitro experiments, antioxidant properties, blood glucose, and AGEs formation were determined. Dill extract was given orally to healthy and diabetic rats. Our results illustrated that different concentrations of dill extract (0.125, 0.25, 0.5, and 1 mg/ml) have potential antiradical and antioxidant activity. Aqueous extract of dill significantly reduced AGEs formation and fructosamine levels, protein carbonyl and also thiol group's oxidation, amyloid cross-β and fragmentation. After 2 months, blood glucose levels (P=0.006) and AGEs formation (P=0.003) significantly reduced in dill treated group compared with untreated diabetic animals. In conclusion, dill can be recommended as herbal medicine for the control and prevention of diabetic complications.
本研究的目的是评估莳萝水提取物的抗糖化和抗氧化特性。在体内和体外实验中，测定了抗氧化特性、血糖和晚期糖基化终末产物（AGEs）的形成。将莳萝提取物口服给予健康大鼠和糖尿病大鼠。我们的结果表明，不同浓度的莳萝提取物（0.125、0.25、0.5和1mg/ml）具有潜在的抗自由基和抗氧化活性。莳萝水提取物显著降低了AGEs的形成、果糖胺水平、蛋白质羰基以及硫醇基团的氧化、淀粉样β-折叠交联和片段化。2个月后，与未治疗的糖尿病动物相比，莳萝治疗组的血糖水平（P=0.006）和AGEs形成（P=0.003）显著降低。总之，莳萝可作为控制和预防糖尿病并发症的草药推荐使用。
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