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长期使用双膦酸盐类药物导致的非典型股骨骨折:病例报告

Atypical femoral fracture due to chronic use of bisphosphonates: case report.

作者信息

Temponi Eduardo Frois, de Carvalho Junior Lúcio Honório, Costa Lincoln Paiva

机构信息

Hospital Madre Teresa, Belo Horizonte, MG, Brazil.

出版信息

Rev Bras Ortop. 2015 Jul 10;50(4):482-5. doi: 10.1016/j.rboe.2015.06.016. eCollection 2015 Jul-Aug.

DOI:10.1016/j.rboe.2015.06.016
PMID:26401508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4563046/
Abstract

The causal relationship between chronic use of bisphosphonates and occurrences of atypical femoral fractures has not yet been established. Nonetheless, it is known that their chronic use is more related to fractures with a pattern differing from that of classical osteoporotic fractures. Atypical fractures are still rare events and the benefit from using bisphosphonates remains greater for prevention and treatment of osteoporosis. There are few studies guiding the diagnosis and management of these fractures, thus making it difficult to achieve better results. In this report, we present the case of an elderly patient with an atypical femoral fracture that was managed in accordance with guidance from the American Society for Bone and Mineral Research.

摘要

长期使用双膦酸盐与非典型股骨骨折的发生之间的因果关系尚未确立。尽管如此,已知长期使用双膦酸盐与骨折的关联更大,其骨折模式不同于典型的骨质疏松性骨折。非典型骨折仍然是罕见事件,使用双膦酸盐预防和治疗骨质疏松症的益处仍然更大。指导这些骨折诊断和管理的研究很少,因此难以取得更好的结果。在本报告中,我们介绍了一例老年非典型股骨骨折患者的病例,该病例是根据美国骨与矿物质研究学会的指导进行处理的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43e4/4563046/9f26e1ab1a4d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43e4/4563046/32ac2591deb3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43e4/4563046/9f26e1ab1a4d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43e4/4563046/32ac2591deb3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43e4/4563046/9f26e1ab1a4d/gr2.jpg

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本文引用的文献

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Atypical femoral fractures, bisphosphonates, and mechanical stress.非典型股骨骨折、双磷酸盐类药物和机械应力。
Curr Osteoporos Rep. 2014 Jun;12(2):189-93. doi: 10.1007/s11914-014-0200-9.
3
Review: epidemiology and pathophysiology of atypical femur fractures.综述:非典型股骨骨折的流行病学和病理生理学。
Curr Osteoporos Rep. 2014 Mar;12(1):65-73. doi: 10.1007/s11914-014-0198-z.
4
[Atypical femoral fractures associated with long-term treatment with bisphosphonates].[与双膦酸盐长期治疗相关的非典型股骨骨折]
Acta Med Port. 2013 Nov-Dec;26(6):746-50. Epub 2013 Dec 20.
5
Epidemiology, radiology and histology of atypical femoral fractures.非典型股骨骨折的流行病学、放射学及组织学
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Atypical femoral fractures: what do we know about them?: AAOS Exhibit Selection.非典型股骨骨折:我们对它们了解多少?:美国骨外科医师学会展览精选
J Bone Joint Surg Am. 2013 Jan 16;95(2):e8 1-13. doi: 10.2106/JBJS.L.00568.
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Is surgery necessary for femoral insufficiency fractures after long-term bisphosphonate therapy?长期双膦酸盐治疗后股骨不足骨折是否需要手术?
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