Cho Sun-Jung, Yun Sang-Moon, Lee Dae-hoon, Jo Chulman, Ho Park Moon, Han Changsu, Ho Koh Young
Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, Republic of Korea.
Departments of Neurology, Korea University Medical College, Ansan Hospital, Danwon-gu, Ansan, Gyeonggi-do, Korea.
J Alzheimers Dis. 2015;47(3):639-43. doi: 10.3233/JAD-150103.
Alzheimer's disease (AD) is the most common type of dementia in the elderly. The accumulation of amyloid-β peptides and tau proteins is the major pathogenic event of AD. There is accumulating evidence that both tau and amyloid-β linked to the small ubiquitin-like modifier (SUMO), which is increased in the brain of AD model mouse. The present study focused on the determination of SUMO1 protein level in AD blood plasma by the ELISA methods. We compared plasma from 80 dementia patients (average age 75.3 y), 89 persons with amnestic mild cognitive impairment (MCI) (average age 73.71 y),and 133 cognitively normal controls (average age 71.97 y). The plasma level of SUMO1 was significantly increased in dementia patients, as compared to control groups. The levels of SUMO1 correlated to decreased Mini-Mental State Examination (r =-0.123, p = 0.029). These results suggest that elevated plasma SUMO1 levels may be associated with AD.
阿尔茨海默病（AD）是老年人中最常见的痴呆类型。淀粉样β肽和tau蛋白的积累是AD的主要致病事件。越来越多的证据表明，tau和淀粉样β都与小泛素样修饰物（SUMO）有关，SUMO在AD模型小鼠的大脑中增加。本研究重点通过酶联免疫吸附测定（ELISA）方法测定AD血浆中SUMO1蛋白水平。我们比较了80名痴呆患者（平均年龄75.3岁）、89名遗忘型轻度认知障碍（MCI）患者（平均年龄73.71岁）和133名认知正常对照者（平均年龄71.97岁）的血浆。与对照组相比，痴呆患者血浆中SUMO1水平显著升高。SUMO1水平与简易精神状态检查表得分降低相关（r = -0.123，p = 0.029）。这些结果表明，血浆SUMO1水平升高可能与AD有关。
