McFarlane Oliwia, Kozakiewicz Mariusz, Wojciechowska Milena, Kędziora-Kornatowska Kornelia
Department of Social and Medical Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, Poland.
Department of Geriatrics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, Poland.
Curr Issues Mol Biol. 2023 Mar 16;45(3):2452-2460. doi: 10.3390/cimb45030160.
Together with development of new pharmaceutical interventions, as well as the introduction of the concept of initial dementia phase, the demand for early diagnosis has been growing. Research on potential blood biomarkers, amazingly attractive, mainly due to the facility of deriving the material, has provided ambiguous results throughout. The existence of an association between ubiquitin and Alzheimer's disease pathology suggests that it could be a potential neurodegeneration biomarker. The present study aims to identify and assess the relationship between ubiquitin with regard to the adequacy as a biomarker of an initial dementia and cognitive decline in the elderly. Method: The study sample was composed of 230 participants: 109 women and 121 men aged 65 and older. The relationships of plasma ubiquitin levels with cognitive performance, gender, and age were analyzed. The assessments were performed in three groups of cognitive functioning level: cognitively normal, mild cognitive impairment, and mild dementia, of which the subjects were divided with the Mini-Mental State Examination (MMSE). Results: No significant disparities in plasma ubiquitin levels for various levels of cognitive functioning were identified. Significantly higher plasma ubiquitin levels in women were found in comparison to men. No significant differences were found in ubiquitin concentrations based on age. Results suggest that ubiquitin does not meet the requirements for qualification as a blood biomarker of an early cognitive decline. In order to thoroughly evaluate the potential of research on ubiquitin in connection to an early neurodegenerative process, further studies are needed.
随着新型药物干预措施的发展以及早期痴呆阶段概念的引入，早期诊断的需求不断增长。对潜在血液生物标志物的研究极具吸引力，主要是因为获取材料较为便捷，但总体结果却并不明确。泛素与阿尔茨海默病病理学之间存在关联，这表明它可能是一种潜在的神经退行性变生物标志物。本研究旨在确定并评估泛素作为老年人初始痴呆和认知衰退生物标志物的充分性之间的关系。方法：研究样本由230名参与者组成：109名女性和121名65岁及以上的男性。分析了血浆泛素水平与认知表现、性别和年龄之间的关系。评估在三组认知功能水平中进行：认知正常、轻度认知障碍和轻度痴呆，其中受试者通过简易精神状态检查表（MMSE）进行划分。结果：未发现不同认知功能水平的血浆泛素水平存在显著差异。与男性相比，女性的血浆泛素水平显著更高。基于年龄未发现泛素浓度存在显著差异。结果表明，泛素不符合作为早期认知衰退血液生物标志物的资格要求。为了全面评估泛素与早期神经退行性过程相关研究的潜力，还需要进一步的研究。
