Quiroz Yakeel T, Willment Kim Celone, Castrillon Gabriel, Muniz Martha, Lopera Francisco, Budson Andrew, Stern Chantal E
Grupo de Neurociencias, Universidad de Antioquia, Medellín, Colombia.
Departments of Psychiatry and Neurology, Massachusetts General Hospital, Boston, MA, USA.
J Alzheimers Dis. 2015;47(4):955-64. doi: 10.3233/JAD-150214.
Brain regions critical to episodic memory are altered during the preclinical stages of Alzheimer's disease (AD). However, reliable means of identifying cognitively-normal individuals at higher risk to develop AD have not been established.
To examine whether functional MRI can detect early functional changes associated with scene encoding in a group of presymptomatic presenilin-1 (PSEN1) E280A mutation carriers.
Participants were 39 young, cognitively-normal individuals from an autosomal dominant early-onset AD kindred, located in Antioquia, Colombia. Participants performed a functional MRI scene encoding task and a post-scan subsequent memory test.
PSEN1 mutation carriers exhibited hyperactivation within medial temporal lobe regions (hippocampus,parahippocampal formation) during successful scene encoding compared to age-matched non-carriers.
Hyperactivation in medial temporal lobe regions during scene encoding is seen in individuals genetically-determined to develop AD years before their clinical onset. Our findings will guide future research with the ultimate goal of using functional neuroimaging in the early detection of preclinical AD.
在阿尔茨海默病（AD）临床前阶段，对情景记忆至关重要的脑区会发生改变。然而，尚未建立识别患AD风险较高的认知正常个体的可靠方法。
研究功能磁共振成像（fMRI）能否检测一组无症状早老素-1（PSEN1）E280A突变携带者中与情景编码相关的早期功能变化。
参与者为来自哥伦比亚安蒂奥基亚一个常染色体显性早发型AD家族的39名年轻认知正常个体。参与者进行了功能磁共振成像情景编码任务和扫描后后续记忆测试。
与年龄匹配的非携带者相比，PSEN1突变携带者在成功进行情景编码期间，内侧颞叶区域（海马体、海马旁结构）表现出过度激活。
在基因决定多年后才会临床发病的AD个体中，情景编码期间内侧颞叶区域出现过度激活。我们的研究结果将指导未来的研究，最终目标是利用功能神经成像在临床前AD的早期检测中发挥作用。
