Ochoa John Fredy, Alonso Joan Francesc, Duque Jon Edinson, Tobón Carlos Andrés, Mañanas Miguel Angel, Lopera Francisco, Hernández Alher Mauricio
Bioinstrumentation and Clinical Engineering Research Group, Bioengineering Program, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
Department of Automatic Control (ESAII), Biomedical Engineering Research Center (CREB), Universitat Politènica de Catalunya (UPC), Barcelona, Spain.
J Alzheimers Dis. 2017;55(3):1195-1205. doi: 10.3233/JAD-160803.
Recent studies report increases in neural activity in brain regions critical to episodic memory at preclinical stages of Alzheimer's disease (AD). Although electroencephalography (EEG) is widely used in AD studies, given its non-invasiveness and low cost, there is a need to translate the findings in other neuroimaging methods to EEG.
To examine how the previous findings using functional magnetic resonance imaging (fMRI) at preclinical stage in presenilin-1 E280A mutation carriers could be assessed and extended, using EEG and a connectivity approach.
EEG signals were acquired during resting and encoding in 30 normal cognitive young subjects, from an autosomal dominant early-onset AD kindred from Antioquia, Colombia. Regions of the brain previously reported as hyperactive were used for connectivity analysis.
Mutation carriers exhibited increasing connectivity at analyzed regions. Among them, the right precuneus exhibited the highest changes in connectivity.
Increased connectivity in hyperactive cerebral regions is seen in individuals, genetically-determined to develop AD, at preclinical stage. The use of a connectivity approach and a widely available neuroimaging technique opens the possibility to increase the use of EEG in early detection of preclinical AD.
近期研究报告称，在阿尔茨海默病（AD）临床前阶段，对情景记忆至关重要的脑区神经活动会增加。尽管脑电图（EEG）因其非侵入性和低成本而在AD研究中被广泛使用，但仍有必要将其他神经影像学方法的研究结果转化为EEG研究。
探讨如何使用EEG和连接性方法来评估和扩展先前在早老素-1 E280A突变携带者临床前阶段使用功能磁共振成像（fMRI）所获得的研究结果。
在30名认知正常的年轻受试者静息和编码过程中采集EEG信号，这些受试者来自哥伦比亚安蒂奥基亚的一个常染色体显性早发型AD家族。先前报道为活跃过度的脑区用于连接性分析。
突变携带者在所分析区域的连接性增加。其中，右侧楔前叶的连接性变化最大。
在临床前阶段，在基因上注定会患AD的个体中，可观察到活跃过度的脑区连接性增加。使用连接性方法和一种广泛可用的神经影像学技术为增加EEG在临床前AD早期检测中的应用提供了可能性。
