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本文引用的文献

1
Evaluation of PSMA PET/CT imaging using a 68Ga-HBED-CC ligand in patients with prostate cancer and the value of early pelvic imaging.使用68Ga-HBED-CC配体对前列腺癌患者进行PSMA PET/CT成像评估及早期盆腔成像的价值
Nucl Med Commun. 2015 Jun;36(6):582-7. doi: 10.1097/MNM.0000000000000290.
2
Contemporary role of salvage lymphadenectomy in patients with recurrence following radical prostatectomy.根治性前列腺切除术后复发患者挽救性淋巴结清扫术的当代作用。
Eur Urol. 2015 May;67(5):839-49. doi: 10.1016/j.eururo.2014.03.019. Epub 2014 Mar 26.
3
Preliminary results for characterization of pelvic lymph nodes in patients with prostate cancer by diffusion-weighted MR-imaging.初步结果表明,扩散加权磁共振成像可用于前列腺癌患者盆腔淋巴结的特征描述。
Invest Radiol. 2010 Jan;45(1):15-23. doi: 10.1097/RLI.0b013e3181bbdc2f.

根治性前列腺切除术后机器人挽救性淋巴结清扫术

Robotic Salvage Lymph Node Dissection After Radical Prostatectomy.

作者信息

Torricelli Fabio C M, Cividanes Arnaldo, Guglielmetti Giuliano B, Coelho Rafael F

机构信息

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, SP, Brasil.

Hospital 9 de Julho, SP. Brasil.

出版信息

Int Braz J Urol. 2015 Jul-Aug;41(4):819; discussion 820. doi: 10.1590/S1677-5538.IBJU.2014.0614.

DOI:10.1590/S1677-5538.IBJU.2014.0614
PMID:26401879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4757015/
Abstract

INTRODUCTION AND OBJECTIVE

Radical prostatectomy is a first-line treatment for localized prostate cancer. However, in some cases, biochemical recurrence associated with imaging-detected nodal metastases may happen. Herein, we aim to present the surgical technique for salvage lymph node dissection after radical prostatectomy.

MATERIALS AND METHODS

A 70 year-old asymptomatic man presented with a prostate-specific antigen (PSA) of 7.45 ng/mL. Digital rectal examination was normal and trans-rectal prostate biopsy revealed a prostate adenocarcinoma Gleason 7 (3+4). Pre-operative computed tomography scan and bone scintigraphy showed no metastatic disease. In other service, the patient underwent a robotic-assisted radical prostatectomy plus obturador lymphadenectomy. Pathologic examination showed a pT3aN0 tumor. After 6 months of follow-up, serum PSA was 1.45 ng/mL. Further investigation with 11C--Choline PET/CT revealed only a 2-cm lymph node close to the left internal iliac artery. The patient was counseled for salvage lymph node dissection.

RESULTS

Salvage lymph node dissection was uneventfully performed. Operative time was 1.5 hour, blood loss was minimal, and there were no intra- or postoperative complications. The patient was discharged from hospital in the 1st postoperative day. After 12 months of follow-up, his PSA was undetectable with no other adjuvant therapy.

CONCLUSION

Robotic salvage pelvic lymph node dissection is an effective option for treatment of patients with biochemical recurrence after radical prostatectomy and only pelvic lymph node metastasis detected by C11-Choline PET/CT.

摘要

引言与目的

根治性前列腺切除术是局限性前列腺癌的一线治疗方法。然而,在某些情况下,可能会发生与影像学检测到的淋巴结转移相关的生化复发。在此,我们旨在介绍根治性前列腺切除术后挽救性淋巴结清扫术的手术技术。

材料与方法

一名70岁无症状男性,前列腺特异性抗原(PSA)为7.45 ng/mL。直肠指检正常,经直肠前列腺活检显示为 Gleason 7(3+4)级前列腺腺癌。术前计算机断层扫描和骨闪烁显像未显示转移性疾病。在其他科室,该患者接受了机器人辅助根治性前列腺切除术加闭孔淋巴结清扫术。病理检查显示为pT3aN0肿瘤。随访6个月后,血清PSA为1.45 ng/mL。进一步的11C-胆碱PET/CT检查仅发现左髂内动脉附近有一个2厘米的淋巴结。该患者接受了挽救性淋巴结清扫术的咨询。

结果

挽救性淋巴结清扫术顺利完成。手术时间为1.5小时,出血量极少,术中及术后均无并发症。患者术后第1天出院。随访12个月后,在未进行其他辅助治疗的情况下,其PSA检测不到。

结论

机器人辅助挽救性盆腔淋巴结清扫术是治疗根治性前列腺切除术后生化复发且仅通过C11-胆碱PET/CT检测到盆腔淋巴结转移患者的有效选择。