Allard U
Endod Dent Traumatol. 1989 Dec;5(6):287-91. doi: 10.1111/j.1600-9657.1989.tb00375.x.
Forty-eight periapical lesions were induced in the mandible of dogs. Subsequently, the dogs were given a single intramuscular injection of either benzylpenicillin, erythromycin, lincomycin or clindamycin. The antibiotic concentration in serum and exudate from the periapical lesions was measured. The highest concentration of benzylpenicillin in serum (4.3 micrograms/ml) was obtained 30 min after the injection and in exudate (1.8 micrograms/ml) 60 min after injection. The highest concentration of erythromycin in serum (0.8 microgram/ml) was reached after 120 min and in exudate (0.6 microgram/ml) 240 min after the injection. The highest concentration of clindamycin in serum (2.3 micrograms/ml) was obtained 120 min after the injection and in the exudate (2.2 micrograms/ml) after 240 min. The highest concentration of lincomycin in serum (4.2 micrograms/ml) was noted 120 min after the injection and in exudate (4.5 micrograms/ml) 240 min after the injection. The results of this study indicated that the sampling method used might be suitable for analyzing the concentration of antibiotics in a clinical situation.
在犬的下颌骨诱发了48个根尖周病变。随后，给这些犬单次肌内注射苄青霉素、红霉素、林可霉素或克林霉素。测量血清和根尖周病变渗出液中的抗生素浓度。注射后30分钟血清中苄青霉素的最高浓度为4.3微克/毫升，注射后60分钟渗出液中为1.8微克/毫升。注射后120分钟血清中红霉素的最高浓度达到0.8微克/毫升，注射后240分钟渗出液中为0.6微克/毫升。注射后120分钟血清中克林霉素的最高浓度为2.3微克/毫升，240分钟后渗出液中为2.2微克/毫升。注射后120分钟血清中林可霉素的最高浓度为4.2微克/毫升，注射后240分钟渗出液中为4.5微克/毫升。本研究结果表明，所采用的采样方法可能适用于临床情况下抗生素浓度的分析。
