Gramunt Nina, Buschke Herman, Sánchez-Benavides Gonzalo, Lipton Richard B, Peña-Casanova Jordi, Diéguez-Vide Faustino, Masramon Xavier, Gispert Juan D, Fauria Karine, Camí Jordi, Molinuevo José L
Clinical Research Program, BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
J Alzheimers Dis. 2015;48(3):613-25. doi: 10.3233/JAD-150237.
The Memory Binding Test (MBT) is a novel test based on the learning of two lists of words, developed to detect early memory impairment suggestive of Alzheimer's disease (AD).
To present and provide reference data of the Spanish MBT in a midlife population of mainly first-degree descendants of AD patients.
472 cognitively unimpaired subjects, aged 45 to 65 and participants of the ALFA STUDY, were included. Raw scores were transformed to scaled scores on which multivariate regression analysis was applied adjusting by age, gender, and education level. A standard linear regression was employed to derive the scaled score adjusted. Sociodemographic corrections were applied and an adjustment table was constructed.
Performance was heterogeneously influenced by sociodemographic factors. Age negatively influenced free recall. Education tends to have an influence in the results showing lower performance with lower education level. Women tend to outperform men in the learning of the first list and total recall. Only a few variables were unaffected by sociodemographic factors such as those related to semantic proactive interference (SPI) and to the retention of learned material. Our results point out that some vulnerability to SPI is expectable in cognitively healthy subjects. Close to 100% of the learned material was maintained across the delay interval.
This study contributes with reference data for the MBT providing the necessary adjustments for sociodemographic characteristics. Our data may prove to be useful for detecting asymptomatic at-risk candidates for secondary prevention studies of AD.
记忆联结测试（MBT）是一项基于学习两组单词列表开发的新型测试，旨在检测提示阿尔茨海默病（AD）的早期记忆障碍。
在以AD患者的主要一级亲属为主的中年人群中呈现并提供西班牙版MBT的参考数据。
纳入472名年龄在45至65岁之间、认知功能未受损且参与ALFA研究的受试者。将原始分数转换为量表分数，并应用多元回归分析，根据年龄、性别和教育水平进行调整。采用标准线性回归得出调整后的量表分数。进行社会人口学校正并构建调整表。
社会人口学因素对测试表现有不同程度的影响。年龄对自由回忆有负面影响。教育程度往往会对结果产生影响，教育水平较低时表现较差。在学习第一组单词列表和总回忆方面，女性往往比男性表现更好。只有少数变量不受社会人口学因素影响，例如与语义前摄干扰（SPI）和所学材料保留相关的变量。我们的结果指出，认知健康的受试者中出现一定程度的SPI易感性是可以预期的。在延迟间隔期间，近100%的所学材料得以保留。
本研究为MBT提供了参考数据，并针对社会人口学特征进行了必要的调整。我们的数据可能对检测AD二级预防研究的无症状高危候选者有用。
