多面性、非肽类α-螺旋模拟物
Multi-Facial, Non-Peptidic α-Helix Mimetics.
作者信息
Lanning Maryanna E, Fletcher Steven
机构信息
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St., Baltimore, MD 21201, USA.
University of Maryland Greenebaum Cancer Center, 22 S. Greene St., Baltimore, MD 21201, USA.
出版信息
Biology (Basel). 2015 Aug 31;4(3):540-55. doi: 10.3390/biology4030540.
Abstract
α-Helices often recognize their target proteins at protein-protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix.
摘要
α-螺旋通常在蛋白质-蛋白质界面通过不止一个识别面来识别其靶蛋白。本综述描述了非肽类α-螺旋模拟物设计的最新进展，这些模拟物可从α-螺旋的多个面再现功能。
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