Liu Pengfei, Feng Yetong, Wang Yi, Zhou Yulai, Zhao Lei
Department of Regeneration Medicine, School of Pharmaceutical Science, Jilin University, Changchun, P.R. China; Department of Anesthesiology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, P.R. China.
Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, P.R. China.
Biomed Mater Eng. 2015;26 Suppl 1:S2133-44. doi: 10.3233/BME-151519.
It has been well-known for many years now that vitamin E is an essential nutrient; however, some of the physiological functions of this vitamin are still far from being understood. In recent years, a series of preclinical and clinical studies proposed a protective role of vitamin E on acute kidney injury (AKI), which has a high morbidity rate and mortality rate in clinical investigations. Based on the benefits associated with vitamin E, such as strong antioxidant function, low toxicity, rare side-effects, and low cost, this therapy strategy has garnered an extensive amount of interest in the scientific community for the development of new therapy modes against AKI. In this review, a concise overview of the application of vitamin E in the treatment of AKI is provided as well as a summary of a series of published data regarding the combination therapy modes and detailed therapy mechanisms of vitamin E-based therapy against AKI. At present, there are critical points of this therapy mode that are still in need of further clarification, meaning the current understanding of the role of vitamin E in the treatment of AKI remains incomplete. However, the development of more reliable pharmacological or biotechnical strategies with vitamin E for the eventual treatment of patients with AKI may guide the next chapter of vitamin E research.
多年来，维生素E一直被公认为是一种必需营养素；然而，这种维生素的一些生理功能仍远未被了解。近年来，一系列临床前和临床研究表明维生素E对急性肾损伤（AKI）具有保护作用，急性肾损伤在临床研究中的发病率和死亡率都很高。基于维生素E的益处，如强大的抗氧化功能、低毒性、罕见的副作用和低成本，这种治疗策略在科学界引起了广泛关注，以开发针对急性肾损伤的新治疗模式。在这篇综述中，简要概述了维生素E在急性肾损伤治疗中的应用，并总结了一系列已发表的数据，这些数据涉及基于维生素E的联合治疗模式以及治疗急性肾损伤的详细治疗机制。目前，这种治疗模式的关键点仍需要进一步阐明，这意味着目前对维生素E在急性肾损伤治疗中作用的理解仍然不完整。然而，开发更可靠的基于维生素E的药理学或生物技术策略以最终治疗急性肾损伤患者可能会引领维生素E研究的新篇章。
