Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul 01757, Republic of Korea.
Nutrients. 2023 Jul 26;15(15):3318. doi: 10.3390/nu15153318.
The causal effects of chondroitin, glucosamine, and vitamin/mineral supplement intake on kidney function remain unknown, despite being commonly used. We conducted a two-sample summary-level Mendelian randomization (MR) analysis to test for causal associations between regular dietary supplement intake and kidney function. Genetic instruments for chondroitin, glucosamine, and vitamin/mineral supplement intake were obtained from a genome-wide association study of European ancestry. Summary statistics for the log-transformed estimated glomerular filtration rate (log-eGFR) were provided by the CKDGen consortium. The multiplicative random-effects inverse-variance weighted method showed that genetically predicted chondroitin and glucosamine intake was causally associated with a lower eGFR (chondroitin, eGFR change beta = -0.113%, standard error (SE) = 0.03%, -value = 2 × 10; glucosamine, eGFR change beta = -0.240%, SE = 0.035%, -value = 6 × 10). However, a genetically predicted vitamin/mineral supplement intake was associated with a higher eGFR (eGFR change beta = 1.426%, SE = 0.136%, -value = 1 × 10). Validation analyses and pleiotropy-robust MR results for chondroitin and vitamin/mineral supplement intake supported the main results. Our MR study suggests a potential causal effect of chondroitin and glucosamine intake on kidney function. Therefore, clinicians should carefully monitor their long-term effects.
尽管软骨素、氨基葡萄糖和维生素/矿物质补充剂在临床上被广泛应用，但它们对肾功能的因果效应仍不清楚。我们进行了两样本汇总水平孟德尔随机化（MR）分析，以检验常规膳食补充剂摄入与肾功能之间的因果关系。软骨素、氨基葡萄糖和维生素/矿物质补充剂摄入的遗传工具来自欧洲血统的全基因组关联研究。CKDGen 联盟提供了经对数转换的估计肾小球滤过率（log-eGFR）的汇总统计数据。乘法随机效应逆方差加权法表明，遗传预测的软骨素和氨基葡萄糖摄入与较低的 eGFR 呈因果关系（软骨素，eGFR 变化β=-0.113%，标准误差（SE）=0.03%，-值=2×10；氨基葡萄糖，eGFR 变化β=-0.240%，SE=0.035%，-值=6×10）。然而，遗传预测的维生素/矿物质补充剂摄入与较高的 eGFR 呈因果关系（eGFR 变化β=1.426%，SE=0.136%，-值=1×10）。软骨素和维生素/矿物质补充剂摄入的验证分析和多效性稳健 MR 结果支持主要结果。我们的 MR 研究表明，软骨素和氨基葡萄糖摄入对肾功能可能存在因果效应。因此，临床医生应仔细监测其长期影响。
