Kleinhout J, Stolte L A, Janssens J, Knoop A A
Eur J Obstet Gynecol Reprod Biol. 1977;7(6):373-6. doi: 10.1016/0028-2243(77)90066-1.
In the exteriorized fetal lamb an experimental study on the influence of the fetal autonomic nervous system upon the heart rate pattern is described by means of blockage of the cholinergic, alpha-adrenergic and beta-adrenergic system. The alpha-adrenergic system proved to have no effect upon heart rate. The beta-adrenergic system had a positive chronotropic effect and the parasympathetic system had a negative chronotropic effect. Beat-to-beat irregularity was independent of a functional alpha-adrenergic system, but at a high basic heart rate disappeared completely after cholinergic blockage and at a low rate after beta-adrenergic blockage. It is concluded that most probably the beat-to-beat irregularity is the result of the competition of the enhancing influence of the beta-adrenergic system and the inhibiting influence of the cholinergic system on fetal heart rate.
在体外化胎羊中，通过阻断胆碱能、α-肾上腺素能和β-肾上腺素能系统，描述了一项关于胎儿自主神经系统对心率模式影响的实验研究。结果表明，α-肾上腺素能系统对心率无影响。β-肾上腺素能系统具有正性变时作用，而副交感神经系统具有负性变时作用。逐搏心律不齐与功能性α-肾上腺素能系统无关，但在高基础心率时，胆碱能阻断后完全消失，在低心率时，β-肾上腺素能阻断后消失。得出的结论是，逐搏心律不齐很可能是β-肾上腺素能系统的增强影响与胆碱能系统对胎儿心率的抑制影响相互竞争的结果。
