R. C. Patel Institute of Pharmaceutical Education and Research, Near Karwand Naka, Shirpur-425 405, Dist-Dhule, Maharashtra, India.
Phytother Res. 2010 Jan;24(1):33-7. doi: 10.1002/ptr.2861.
Oleanolic acid is a molecule of current therapeutic interest. In the present study, oleanolic acid isolated from the cuticular epithelium of Viscum articulatum Burm. f. (Viscaceae) was investigated for its protective effects on gentamicin-induced renal damage in rats. Nephrotoxicity was induced in rats by intraperitoneal injection of gentamicin at a dose of 100 mg/kg/day for 8 days. The effect of Oleanolic acid administered orally at doses 40, 60 and 80 mg/kg/day was assessed biochemically by determination of albumin, urea and creatinine in serum and urine samples and also through histopathological examination of the kidneys. Oleanolic acid protected the rat kidneys from gentamicin-induced nephrotoxicity as evident from a decrease in the serum and urine levels of creatinine, albumin and urea. Oleanolic acid also protected the rat kidneys from histological alterations induced by gentamicin and also improved the glomerular filtration rate. Compared with an earlier report on intraperitoneal administration of oleanolic acid in paracetamol-induced nephrotoxicity in rats, the data show that orally administered oleanolic acid also exerted a nephroprotective effect even in the case of a nephrotoxicant such as gentamicin, which directly deteriorates the kidney function without prior metabolism.
齐墩果酸是一种具有当前治疗意义的分子。在本研究中，从槲寄生（桑寄生科）的表皮中分离出的齐墩果酸，用于研究其对庆大霉素诱导的大鼠肾损伤的保护作用。通过腹腔注射 100mg/kg/天的庆大霉素 8 天，在大鼠中诱导肾毒性。通过测定血清和尿液样本中的白蛋白、尿素和肌酐，以及通过肾脏组织病理学检查，评估口服 40、60 和 80mg/kg/天剂量的齐墩果酸的效果。齐墩果酸可保护大鼠肾脏免受庆大霉素诱导的肾毒性，其表现为血清和尿液中肌酐、白蛋白和尿素水平降低。齐墩果酸还可保护大鼠肾脏免受庆大霉素引起的组织学改变，并改善肾小球滤过率。与先前关于腹腔内给予齐墩果酸在对乙酰氨基酚诱导的大鼠肾毒性中的作用的报告相比，数据表明，即使在庆大霉素等直接损害肾功能而无需事先代谢的肾毒性物质的情况下，口服给予齐墩果酸也能发挥肾脏保护作用。
