Battista Natalia, Bari Monica, Maccarrone Mauro
Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
European Center for Brain Research/IRCCS Santa Lucia Foundation, Rome, Italy.
Handb Exp Pharmacol. 2015;231:341-65. doi: 10.1007/978-3-319-20825-1_12.
The lasting research on the endocannabinoid system (ECS) has now provided solid and convincing evidence that proves the detrimental effects of recreational drug abuse (a growing habit among teenagers) on fertility. Endocannabinoids (eCBs) affect reproductive events from gametogenesis to fertilization, from embryo implantation to the final outcome of pregnancy and, thus, they have been proposed as suitable biomarkers to predict the reproductive potential of male and female gametes in clinical practice. Novel tools for reproductive medicine are highly sought after, and here we report the latest findings on the impact of the ECS on fertility, demonstrating how basic research can be translated into new medical strategies.
对内源性大麻素系统（ECS）的长期研究现已提供了确凿且令人信服的证据，证明了娱乐性药物滥用（青少年中日益普遍的一种习惯）对生育能力的有害影响。内源性大麻素（eCBs）影响从配子发生到受精、从胚胎着床到妊娠最终结局的生殖过程，因此，它们被提议作为临床实践中预测男性和女性配子生殖潜力的合适生物标志物。生殖医学的新工具备受追捧，在此我们报告关于ECS对生育能力影响的最新研究结果，展示了基础研究如何转化为新的医学策略。
