du Plessis Stefan S, Agarwal Ashok, Syriac Arun
Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
American Center for Reproductive Medicine, Cleveland Clinic, 10681 Carnegie Avenue, Cleveland, OH, 44195, USA.
J Assist Reprod Genet. 2015 Nov;32(11):1575-88. doi: 10.1007/s10815-015-0553-8. Epub 2015 Aug 16.
Marijuana has the highest consumption rate among all of the illicit drugs used in the USA, and its popularity as both a recreational and medicinal drug is increasing especially among men of reproductive age. Male factor infertility is on the increase, and the exposure to the cannabinoid compounds released by marijuana could be a contributing cause. The endocannabinoid system (ECS) is deeply involved in the complex regulation of male reproduction through the endogenous release of endocannabinoids and binding to cannabinoid receptors. Disturbing the delicate balance of the ECS due to marijuana use can negatively impact reproductive potential. Various in vivo and in vitro studies have reported on the empirical role that marijuana plays in disrupting the hypothalamus-pituitary-gonadal axis, spermatogenesis, and sperm function such as motility, capacitation, and the acrosome reaction. In this review, we highlight the latest evidence regarding the effect of marijuana use on male fertility and also provide a detailed insight into the ECS and its significance in the male reproductive system.
在美国使用的所有非法药物中，大麻的消费率最高，而且它作为一种娱乐性和药用药物的受欢迎程度正在上升，尤其是在育龄男性中。男性因素导致的不孕症正在增加，接触大麻释放的大麻素化合物可能是一个促成因素。内源性大麻素系统（ECS）通过内源性大麻素的释放以及与大麻素受体的结合，深度参与男性生殖的复杂调节。由于使用大麻而扰乱ECS的微妙平衡会对生殖潜力产生负面影响。各种体内和体外研究都报告了大麻在破坏下丘脑-垂体-性腺轴、精子发生以及精子功能（如运动能力、获能和顶体反应）方面所起的实证作用。在这篇综述中，我们强调了关于使用大麻对男性生育能力影响的最新证据，并详细深入地探讨了ECS及其在男性生殖系统中的重要性。
