Khedr Eman M, Elbeh Khaled A, Abdel Baky Ahmed, Abo-Elfetoh Noha, El-Hammady Dina H, Korashy Fatma
Department of Neuropsychiatry, Assiut University Hospital, Assiut, Egypt.
Department of Rheumatology and Rehabilitation, Assiut University Hospital, Assiut, Egypt.
Restor Neurol Neurosci. 2015;33(4):435-45. doi: 10.3233/RNN-150507.
Purpose of this study was to evaluate the long term efficacy of repetitive sacral root magnetic stimulation (rSMS) in patients with monosymptomatic nocturnal enuresis (MNE).
Forty four patients were randomized to receive either sham or real repetitive sacral root magnetic stimulation (rSMS; 15 Hz with a total of 1500 pulses/session) for 10 sessions. Evaluation was performed before starting treatment, immediately after the 5th and 10th treatment session, and 1 month later, using frequency of enuresis/week, visual analogue scale (VAS) and quality of life as outcome measures. Resting and active motor thresholds of gastrocnemius muscles were measured before and after the end of sessions.
Both treatment and control groups were comparable for baseline measures of frequency of enuresis, and VAS. The mean number of wet nights/week was significantly reduced in patients who received real rSMS. This improvement was maintained 1 month after the end of treatment. Patients receiving real-rSMS also reported an improvement in VAS ratings and quality of life. A significant reduction of resting motor threshold was recorded after rSMS in the real group while no such changes were observed in the sham group.
These findings suggest that rSMS has potential as an adjuvant treatment for MNE and deserves further study.
本研究旨在评估重复骶神经根磁刺激（rSMS）对单症状性夜间遗尿症（MNE）患者的长期疗效。
44例患者被随机分为两组，分别接受假刺激或真正的重复骶神经根磁刺激（rSMS；15赫兹，每次1500个脉冲），共治疗10次。在治疗开始前、第5次和第10次治疗后立即以及1个月后进行评估，以遗尿频率/周、视觉模拟量表（VAS）和生活质量作为评估指标。在治疗结束前后测量腓肠肌的静息和主动运动阈值。
治疗组和对照组在遗尿频率和VAS的基线测量方面具有可比性。接受真正rSMS治疗的患者每周尿床的平均次数显著减少。这种改善在治疗结束后1个月仍得以维持。接受真正rSMS治疗的患者还报告其VAS评分和生活质量有所改善。真正治疗组在rSMS后静息运动阈值显著降低，而假刺激组未观察到此类变化。
这些发现表明，rSMS有潜力作为MNE的辅助治疗方法，值得进一步研究。
