接受脂质乳剂的极低出生体重儿的高甘油三酯血症。
Hypertriglyceridemia in extremely low birth weight infants receiving lipid emulsions.
作者信息
Holtrop P, Swails T, Riggs T
机构信息
Department of Pediatrics, William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.
William Beaumont Hospital Research Institute, Beaumont Children's Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.
出版信息
J Neonatal Perinatal Med. 2015;8(2):133-6. doi: 10.3233/NPM-15814099.
OBJECTIVE
To determine the prevalence of high TG levels in extremely low birth weight (ELBW) infants and what the risk factors are for high TG levels.
STUDY DESIGN
We performed a prospective observational study of triglyceride concentrations in extremely low birth weight infants receiving lipid infusions. Lipid infusions were begun at 0.5 grams/kg/day at age one day and the dose advanced by 0.5 grams/kg/day. Triglyceride concentrations were drawn when the dose reached 1 and 2 grams/kg/day. We compared infants with normal triglyceride levels (≤200 mg/dl) with those with elevated triglyceride levels (>200 mg/dl) with univariate and multivariate analysis.
RESULTS
There were 75 infants included in the analysis. Twenty (26.7% , 95% CI = 16.6-36.7%) had triglyceride levels >200 mg/dl. On multiple logistic regression analysis, lower birth weight was associated with the risk of an elevated triglyceride level. Triglyceride levels >200 mg/dl did not predict future mortality or morbidity.
CONCLUSION
Elevated TG levels occur commonly in ELBW infants and are associated with a lower birth weight.
目的
确定极低出生体重（ELBW）婴儿中高甘油三酯（TG）水平的患病率以及高TG水平的风险因素有哪些。
研究设计
我们对接受脂质输注的极低出生体重婴儿的甘油三酯浓度进行了一项前瞻性观察研究。脂质输注在出生一天时以0.5克/千克/天开始，剂量每天增加0.5克/千克/天。当剂量达到1克/千克/天和2克/千克/天时采集甘油三酯浓度。我们通过单因素和多因素分析比较了甘油三酯水平正常（≤200毫克/分升）的婴儿和甘油三酯水平升高（>200毫克/分升）的婴儿。
结果
分析纳入了75名婴儿。20名（26.7%，95%CI = 16.6 - 36.7%）婴儿的甘油三酯水平>200毫克/分升。在多因素逻辑回归分析中，较低的出生体重与甘油三酯水平升高的风险相关。甘油三酯水平>200毫克/分升并不能预测未来的死亡率或发病率。
结论
高TG水平在ELBW婴儿中普遍存在，并且与较低的出生体重相关。
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