Stambough Jeffrey B, Xiong Ao, Baca Geneva R, Wu Ningying, Callaghan John J, Clohisy John C
Washington University School of Medicine, Department of Orthopaedic Surgery, St Louis, Missouri.
Washington University School of Medicine, Division of Biostatistics, St Louis, Missouri.
J Arthroplasty. 2016 Feb;31(2):429-33. doi: 10.1016/j.arth.2015.08.019. Epub 2015 Aug 30.
In a new health care economy, there is an emerging need to understand and quantify predictors of total hip arthroplasty (THA) outcomes. We investigated the association between preoperative radiographic disease (as measured quantitatively by joint space width [JSW]) and patient-reported function, activity, pain, and quality of life after THA.
We retrospectively analyzed 146 patients (146 hips) 55 years or younger with a diagnosis of osteoarthritis who underwent cementless THA between January 2009 and December 2010. Preoperative pelvic radiographs were measured by 1 author blinded to clinical outcomes to establish JSW, defined as the shortest distance between the femoral head margin and the superolateral weight-bearing portion of the acetabulum. The JSW value was treated as a continuous variable when applied to statistical modeling. The relationship between the JSW and the improvement of clinical outcome was examined via a general linear modeling approach with adjustments for patients' age, body mass index, and sex.
We identified an inverse relationship between preoperative JSW and improvements in functional, activity, pain, and quality of life. We found that, as JSW decreased by 1 mm, the outcome measure improvements were modified Harris Hip Score of 6.3 (p<0.001); SF-12 physical: 2.1 (p=0.027); WOMAC-pain: 4.8 (p=0.01); and UCLA Activity: 0.44 (p=0.02).
Our results demonstrate that patients with greater preoperative joint space have less predictable improvement in terms of function, pain relief, and activity. These findings suggest that THA in young patients with a JSW less than 1.5 to 2 mm provides more predictable improvements in pain and functional outcomes.
在新的医疗保健经济环境下,了解并量化全髋关节置换术(THA)预后的预测因素的需求日益凸显。我们研究了术前影像学疾病(通过关节间隙宽度[JSW]进行定量测量)与患者报告的THA术后功能、活动、疼痛及生活质量之间的关联。
我们回顾性分析了2009年1月至2010年12月期间接受非骨水泥型THA的146例55岁及以下诊断为骨关节炎的患者(146髋)。术前骨盆X线片由1名对临床结果不知情的作者测量以确定JSW,JSW定义为股骨头边缘与髋臼上外侧负重部分之间的最短距离。在应用于统计建模时,JSW值被视为连续变量。通过一般线性建模方法,对患者的年龄、体重指数和性别进行调整,研究JSW与临床结果改善之间的关系。
我们发现术前JSW与功能、活动、疼痛及生活质量的改善之间存在负相关关系。我们发现,随着JSW每减少1毫米,结果测量指标的改善情况为:改良Harris髋关节评分提高6.3分(p<0.001);SF-12身体维度提高2.1分(p=0.027);WOMAC疼痛评分提高4.8分(p=0.01);加州大学洛杉矶分校(UCLA)活动评分提高0.44分(p=0.02)。
我们的结果表明,术前关节间隙较大的患者在功能、疼痛缓解和活动方面的改善较难预测。这些发现表明,对于JSW小于1.5至2毫米的年轻患者,THA在疼痛和功能预后方面提供了更可预测的改善。