骨佩吉特病
Paget Disease of Bone.
作者信息
Al-Rashid Mamun, Ramkumar Dipak B, Raskin Kevin, Schwab Joseph, Hornicek Francis J, Lozano-Calderón Santiago A
机构信息
Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Department of Orthopaedic Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA.
出版信息
Orthop Clin North Am. 2015 Oct;46(4):577-85. doi: 10.1016/j.ocl.2015.06.008.
The current understanding of Paget disease of bone (PDB) has vastly changed since Paget described the first case in 1877. Medical management of this condition remains the mainstay of treatment. Surgical intervention is usually only used in fractures through pagetic bone, need for realignment to correct deformity in major long bones, prophylactic treatment of impending fractures, joint arthroplasty in severe arthritis, or spinal decompression in cases of bony compression of neural elements. Advances in surgical technique have allowed early return to function and mobilization. Despite medical and surgical intervention, a small subset of patients with PDB develops Paget sarcoma.
自1877年佩吉特首次描述骨佩吉特病（PDB）以来，目前对该病的认识已发生了巨大变化。这种疾病的药物治疗仍然是主要的治疗方法。手术干预通常仅用于经畸形性骨炎骨的骨折、为矫正主要长骨畸形而进行的重新排列、对即将发生的骨折的预防性治疗、严重关节炎中的关节置换术，或在神经元件受到骨压迫的情况下进行的脊柱减压。手术技术的进步使患者能够早日恢复功能并开始活动。尽管进行了药物和手术干预，但一小部分PDB患者仍会发展为佩吉特肉瘤。
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