Ogurtsova Ekaterina K, Makarieva Tatyana N, Korolkova Yuliya V, Andreev Yaroslav A, Mosharova Irina V, Denisenko Vladimir A, Dmitrenok Pavel S, Lee Yeon-Ju, Grishin Eugene V, Stonik Valentin A
Nat Prod Commun. 2015 Jul;10(7):1171-3.
The guanidine alkaloids, dihydropulchranin A (2), prepared from pulchranin A from the sponge Monanchora pulchra, and hexadecylguanidine (3), a synthetic analog of pulchranins, were studied for their TRPV channel-regulating activities. Compound 2 was active as an inhibitor of rTRPV1 and hTRPV3 receptors with EC50 values of 24.3 and 59.1 μM, respectively. Hexadecylguanidine (3) was not active against these receptors.
