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单枝海绵胍生物碱A和B，来自远东海洋海绵美丽单枝海绵的新型杂合五环胍生物碱。

Monanchoxymycalins A and B, New Hybrid Pentacyclic Guanidine Alkaloids from the Far-Eastern Marine Sponge Monanchora pulchra.

作者信息

Tabakmakher Kseniya M, Makarieva Tatyana N, Shubina Larisa K, Denisenko Vladimir A, Popov Roman S, Kuzmich Aleksandra S, Lee Hyi-Seung, Lee Yeon-Ju, Stonik Valentin A

出版信息

Nat Prod Commun. 2016 Dec;11(12):1817-1820.

PMID:30508341
Abstract

The new pentacyclic guanidine alkaloids, monanchoxymycalin A (1) and monanchoxymycalin B (2) were isolated from the Far-Eastern marine sponge Monanchora pulchra. Their structures were assigned on the basis of detailed analysis of lD- and 2D-NMR spectroscopic and mass spectrometric data. Compounds 1 and 2 exhibited potent cytotoxic activities against cervical epithelioid carcinoma HeLa cells and breast adenocarcinoma MDA-MB231 cells.

摘要

从远东海洋海绵Monanchora pulchra中分离出了新的五环胍生物碱，单环草苔虫素A（1）和单环草苔虫素B（2）。它们的结构是在对一维和二维核磁共振光谱数据以及质谱数据进行详细分析的基础上确定的。化合物1和2对宫颈上皮样癌细胞HeLa和乳腺腺癌MDA-MB231细胞表现出强大的细胞毒性活性。

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