A-型和B-型DNA双链体中5-羟甲基胞嘧啶（5-hmC）与其3'-相邻碱基之间水桥氢键的形成
Water-bridged hydrogen bond formation between 5-hydroxylmethylcytosine (5-hmC) and its 3'-neighbouring bases in A- and B-form DNA duplexes.
作者信息
Wang Rui, Ranganathan Srivathsan V, Valsangkar Vibhav A, Magliocco Stephanie M, Shen Fusheng, Chen Alan, Sheng Jia
机构信息
Department of Chemistry, The RNA Institute, University at Albany, State University of New York, 1400 Washington Ave., Albany, NY 12222, USA.
出版信息
Chem Commun (Camb). 2015 Nov 25;51(91):16389-92. doi: 10.1039/c5cc06563a.
5-Hydroxylmethylcytosine (5hmC) has been recognized as the sixth base with important biological functions in many tissues and cell types. We present here the high-resolution crystal structures and molecular simulation studies of both A-form and B-form DNA duplexes containing 5hmC. We observed that 5hmC interacts with its 3'-neighboring bases through water-bridged hydrogen bonds and these interactions may affect the further oxidation of 5hmC.
5-羟甲基胞嘧啶（5hmC）已被公认为在许多组织和细胞类型中具有重要生物学功能的第六种碱基。我们在此展示了含有5hmC的A-型和B-型DNA双链体的高分辨率晶体结构及分子模拟研究。我们观察到，5hmC通过水桥氢键与其3'相邻碱基相互作用，且这些相互作用可能会影响5hmC的进一步氧化。
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