Hussain Mehboob A, Song Woo-Jin, Wolfe Andrew
Divisions of Metabolism and Pediatric Endocrinology, Departments of Medicine, Pediatrics, Biological Chemistry and Physiology, Johns Hopkins University, Baltimore, MD, USA.
Divisions of Metabolism and Pediatric Endocrinology, Departments of Medicine, Pediatrics, Biological Chemistry and Physiology, Johns Hopkins University, Baltimore, MD, USA.
Trends Endocrinol Metab. 2015 Oct;26(10):564-572. doi: 10.1016/j.tem.2015.07.008.
While kisspeptin was initially found to function as a metastasis suppressor, after identification of its receptor KISS1R and their expression profiles in tissues such as the hypothalamus and adrenals, kisspeptin and KISS1R were predominantly assigned endocrine functions, including regulating puberty and fertility through their actions on hypothalamic gonadotropin releasing hormone production. More recently, an alter ego for kisspeptin has emerged, with a significant role in regulating glucose homeostasis, insulin secretion, as well as food intake and body composition, and deficient kisspeptin signaling results in reduced locomotor activity and increased adiposity. This review highlights these recent observations on the role of kisspeptin in metabolism as well as several key questions that need to be addressed in the future.
虽然最初发现亲吻素具有转移抑制功能，但在确定其受体KISS1R及其在下丘脑和肾上腺等组织中的表达谱后，亲吻素和KISS1R主要被赋予内分泌功能，包括通过对下丘脑促性腺激素释放激素产生的作用来调节青春期和生育能力。最近，亲吻素又展现出了另一方面的作用，在调节葡萄糖稳态、胰岛素分泌以及食物摄入和身体组成方面发挥着重要作用，而亲吻素信号不足会导致运动活性降低和肥胖增加。本综述重点介绍了关于亲吻素在新陈代谢中的作用的这些最新观察结果，以及未来需要解决的几个关键问题。
