Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Department of Physiology and Biomedical Engineering, Mayo Clinic Arizona, Scottsdale, AZ, USA.
FEBS Lett. 2022 Mar;596(5):607-619. doi: 10.1002/1873-3468.14282. Epub 2022 Jan 19.
Pancreatic β cells secrete insulin in response to glucose, a process that is regulated at multiple levels, including a network of input signals from other organ systems. Impaired islet function contributes to the pathogenesis of type 2 diabetes mellitus (T2DM), and targeting inter-organ communications, such as GLP-1 signalling, to enhance β-cell function has been proven to be a successful therapeutic strategy in the last decade. In this review, we will discuss recent advances in inter-organ communication from the metabolic, immune and neural system to pancreatic islets, their biological implication in normal pancreas endocrine function and their role in the (mal)adaptive responses of islet to nutrition-induced stress.
胰岛β细胞响应葡萄糖分泌胰岛素，这一过程受到多个层面的调控，包括来自其他器官系统的输入信号网络。胰岛功能受损是 2 型糖尿病（T2DM）发病机制的一部分，靶向器官间通讯，如 GLP-1 信号，以增强β细胞功能，在过去十年中已被证明是一种成功的治疗策略。在这篇综述中，我们将讨论代谢、免疫和神经系统到胰岛的器官间通讯的最新进展，它们在正常胰腺内分泌功能中的生物学意义，以及它们在胰岛对营养诱导应激的适应性反应中的作用。
