急性肾损伤：连接衰老与固有免疫以实现清除
ARF: connecting senescence and innate immunity for clearance.
作者信息
Kearney Alper Y, Anchang Benedict, Plevritis Sylvia, Felsher Dean W
机构信息
Division of Oncology, Departments of Medicine and Pathology, Molecular Imaging Program, Stanford University, Stanford, CA 94305, USA.
Current Address: Genitourinary Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Aging (Albany NY). 2015 Sep;7(9):613-5. doi: 10.18632/aging.100813.
We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as well as recruitment of innate immune activation. Our observations have possible implications for mechanisms of therapeutic resistance to targeted oncogene inactivation.
我们发现有证据表明，ARF和p53通过不同机制对MYC失活后的肿瘤消退至关重要。ARF通过不依赖p53的影响，是MYC调节细胞衰老诱导和先天免疫激活募集所需基因表达所必需的。我们的观察结果可能对靶向癌基因失活的治疗耐药机制有影响。
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