Yaylak Barıs, Ede Huseyin, Baysal Erkan, Altıntas Bernas, Akyuz Sukru, Sevuk Utkan, Erdoğan Guney, Comert Nuri, Cakmak Ender Ozgun, Altındag Rojhat, Karahan Zulkuf, Bilge Onder, Cevik Kemal
Department of Cardiology, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakır, Turkey.
Cardiol J. 2016;23(1):100-6. doi: 10.5603/CJ.a2015.0061. Epub 2015 Sep 28.
Acute inferior ST-segment elevation myocardial infarction (STEMI) is associated with increased in-hospital morbidity and mortality particularly among patients with coexisting right ventricular (RV) involvement. High neutrophil to lymphocyte ratio (NLR) is an independent predictor of major adverse cardiac events and mortality in patients with myocardial infarction. This study evaluated the relationship between the NLR and RV dysfunction (RVD) in patients with inferior STEMI who underwent primary percutaneous coronary intervention (PCI).
A total of 213 subjects with inferior STEMI were divided into two groups according to the presence of RVD. The groups were compared according to NLR and receiver operating characteristic (ROC) analysis was performed to access the predictability of NLR on having RVD.
The NLR was significantly higher in the group with RVD compared to that without RVD (p < 0.001). In ROC analysis, NLR > 3.5 predicted RVD with sensitivity of 83% and specificity of 55%. In a multivariate regression analysis, NLR remained an independent predictor of RVD (OR 1.55, 95% CI 1.285-1.750, p < 0.001).
NLR was an independent predictor of RVD in patients with inferior STEMI undergoing primary PCI.
急性下壁ST段抬高型心肌梗死（STEMI）与住院期间发病率和死亡率增加相关，尤其是在合并右心室（RV）受累的患者中。高中性粒细胞与淋巴细胞比值（NLR）是心肌梗死患者主要不良心脏事件和死亡率的独立预测指标。本研究评估了接受直接经皮冠状动脉介入治疗（PCI）的下壁STEMI患者中NLR与右心室功能障碍（RVD）之间的关系。
根据是否存在RVD，将213名下壁STEMI患者分为两组。根据NLR对两组进行比较，并进行受试者工作特征（ROC）分析，以评估NLR对RVD的预测能力。
与无RVD的组相比，有RVD的组NLR显著更高（p < 0.001）。在ROC分析中，NLR > 3.5预测RVD的敏感性为83%，特异性为55%。在多变量回归分析中，NLR仍然是RVD的独立预测指标（OR 1.55，95%CI 1.285 - 1.750，p < 0.001）。
NLR是接受直接PCI的下壁STEMI患者RVD的独立预测指标。
