Department of Cardiology, The Affiliated Hospital of Putian University, Putian University, No. 999 Dongzhen East Road, Licheng District, Putian, 351100, Fujian, China.
Sci Rep. 2021 Jun 1;11(1):11506. doi: 10.1038/s41598-021-91082-w.
There are many clinical scoring criteria for predicting the risk of death in patients with acute ST-segment elevation myocardial infarction (STEMI), but most of the indicators are complex to calculate and are not suitable for use in primary hospitals. Neutrophil to lymphocyte ratio (NLR) and red cell distribution width (RDW) are blood routine indicators that are easy to obtain and may help primary hospitals to evaluate the risk of death in patients with STEMI. Our aim was to explore the predictive value of NLR combined with RDW in the long-term prognosis of patients with STEMI after emergency percutaneous coronary intervention (PCI). A total of 181 patients with STEMI who underwent emergency PCI in the Affiliated Hospital of Pu-tian University from January 2017 to August 2018 were selected. Clinical profile, prognosis of all patients were collected. P value < 0.05 was considered significant. In all patients, cardiovascular death during the follow-up period was defined as cardiovascular death group, and surviving during the follow-up period was defined as survival group. There were no significant differences in demography and comorbidities between the two groups. The differences between the two groups in NLR, RDW, C-reactive protein, N-terminal-pro B type natriuretic peptide were statistically significant (P < 0.01). Binary logistic regression analysis showed that NLR (OR = 1.122, 95% CI 1.041 ~ 1.210, P = 0.003) and RDW (OR = 1.288, 95% CI 1.126 ~ 1.472, P = 0.0005) were important predictors of mortality in patients with STEMI (P < 0.05). Kaplan-Meier analysis showed that as the NLR increased, the risk of death increased (P < 0.001). In conclusion, NLR and RDW are independent predictors of cardiovascular death in patients with STEMI, and they have a certain predictive value.
有许多用于预测急性 ST 段抬高型心肌梗死（STEMI）患者死亡风险的临床评分标准，但大多数指标计算复杂，不适合在基层医院使用。中性粒细胞与淋巴细胞比值（NLR）和红细胞分布宽度（RDW）是易于获得的血常规指标，可能有助于基层医院评估 STEMI 患者的死亡风险。我们的目的是探讨 NLR 联合 RDW 对行急诊经皮冠状动脉介入治疗（PCI）的 STEMI 患者长期预后的预测价值。选择 2017 年 1 月至 2018 年 8 月在莆田学院附属医院行急诊 PCI 的 181 例 STEMI 患者，收集患者的临床资料，随访所有患者的预后。P 值＜0.05 为差异有统计学意义。在所有患者中，随访期间发生心血管死亡定义为心血管死亡组，随访期间生存定义为生存组。两组患者的人口统计学和合并症比较差异无统计学意义。两组 NLR、RDW、C 反应蛋白、N 末端 B 型利钠肽前体比较差异有统计学意义（P＜0.01）。二元逻辑回归分析显示，NLR（OR＝1.122，95％CI 1.041～1.210，P＝0.003）和 RDW（OR＝1.288，95％CI 1.126～1.472，P＝0.0005）是 STEMI 患者死亡的重要预测因素（P＜0.05）。Kaplan-Meier 分析显示，随着 NLR 的增加，死亡风险增加（P＜0.001）。结论 NLR 和 RDW 是 STEMI 患者心血管死亡的独立预测因素，具有一定的预测价值。
