Localization of multiple dipoles: mathematical programming approaches.

Although there has been progress in EEG and evoked potential analysis, the identification of underlying neural activity has eluded researchers despite its importance. This paper introduces the application of mathematical programming techniques to the "inverse" problem of three-dimensional localization of brain activity from scalp potentials. Preliminary computer experience with these optimization methods reported herein, yields encouraging results on simulated data and points new directions for research.