Scherg M, Von Cramon D
Electroencephalogr Clin Neurophysiol. 1985 Jan;62(1):32-44. doi: 10.1016/0168-5597(85)90033-4.
A new spatio-temporal dipole model is presented, which enables prediction and analysis of scalp potential wave forms due to spatio-temporal overlap of multiple generators. Each generator is thought to represent a local neural subset, the electric activity of which can be modelled by an equivalent dipole with stationary location and orientation closely related to the spatial organization of the neural subset. The temporal course of dipole magnitude is assumed to depict the external far field due to the compound discharge processes of the generator. Simulations of uni- and bilateral dipoles within the temporal lobe, oriented vertically and horizontally, demonstrate how spatio-temporal overlap mag bring about the 'vertex response' of the late AEP and the wave form changes observed over temporal sites. Analyses of late AEPs reported for a coronal chain of electrodes by Peronnet et al. (1974) and Vaughan et al. (1980) revealed that the wave forms in the 60-250 msec range could be perfectly matched at all electrodes by model wave forms due to 2 bilateral sources within the temporal lobe. Their locations, orientations and their latency difference of about 30 msec suggest consistently that the sequential activation of primary and secondary auditory cortices is the predominant source to the late AEPs.
本文提出了一种新的时空偶极子模型，该模型能够对由于多个发生器的时空重叠而产生的头皮电位波形进行预测和分析。每个发生器被认为代表一个局部神经子集，其电活动可以用一个等效偶极子来建模，该偶极子的位置和方向固定，且与神经子集的空间组织密切相关。偶极子大小的时间进程被假定为描绘了由于发生器的复合放电过程而产生的外部远场。对颞叶内垂直和水平方向的单侧和双侧偶极子进行的模拟，展示了时空重叠如何导致晚期听觉诱发电位（AEP）的“顶点反应”以及在颞部记录点观察到的波形变化。佩罗内等人（1974年）和沃恩等人（1980年）对冠状电极链记录的晚期AEP进行的分析表明，在60 - 250毫秒范围内，所有电极处的波形都可以与颞叶内两个双侧源产生的模型波形完美匹配。它们的位置、方向以及约30毫秒的潜伏期差异一致表明，初级和次级听觉皮层的顺序激活是晚期AEP的主要来源。
