Aghaloo Tara, Hazboun Renna, Tetradis Sotirios
Section of Oral and Maxillofacial Surgery, Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, 10833 Le Conte Ave., Los Angeles, CA 90095-1668, USA.
Section of Special Patient Care, Division of Advanced Prosthodontics and Section of Restorative Dentistry, Division of Regenerative and Constitutive Sciences, UCLA School of Dentistry, 10833 Le Conte Ave., Los Angeles, CA 90095-1668, USA.
Oral Maxillofac Surg Clin North Am. 2015 Nov;27(4):489-96. doi: 10.1016/j.coms.2015.06.001. Epub 2015 Sep 26.
Osteonecrosis of the jaw (ONJ) is a multifactorial disease in patients with primary or metastatic bone malignancy or osteoporosis undergoing systemic antiresorptive therapy, where pathophysiology has not yet been fully determined. The staging of ONJ is based on severity of symptoms and extent of clinical and radiographic findings. Treatment strategies range from conservative local wound care to aggressive resective surgery of all necrotic bone. The first ONJ cases were reported in 2003 and 2004, and although significant progress has been made in our understanding of the disease, much more work needs to be done to completely explain its pathophysiology.
颌骨骨坏死（ONJ）是一种多因素疾病，发生于患有原发性或转移性骨恶性肿瘤或骨质疏松症且正在接受全身抗吸收治疗的患者中，其病理生理学尚未完全明确。ONJ的分期基于症状的严重程度以及临床和影像学检查结果的范围。治疗策略从保守的局部伤口护理到对所有坏死骨进行积极的切除手术不等。首例ONJ病例于2003年和2004年被报道，尽管我们对该疾病的认识已取得显著进展，但仍需要开展更多工作以全面解释其病理生理学。
