果蝇肌肉中的JAK/STAT信号传导控制针对寄生蜂感染的细胞免疫反应。
JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection.
作者信息
Yang Hairu, Kronhamn Jesper, Ekström Jens-Ola, Korkut Gül Gizem, Hultmark Dan
机构信息
Department of Molecular Biology, Umeå University, Umeå, Sweden.
Department of Molecular Biology, Umeå University, Umeå, Sweden Institute of Biomedical Technology BMT Tampere University, Tampere, Finland.
出版信息
EMBO Rep. 2015 Dec;16(12):1664-72. doi: 10.15252/embr.201540277. Epub 2015 Sep 27.
The role of JAK/STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK/STAT signaling in somatic muscles of the Drosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes. Deletion of upd2 or upd3, but not the related os (upd1) gene, reduced the cellular immune response, and suppression of the JAK/STAT pathway in muscle cells reduced the encapsulation of wasp eggs and the number of circulating lamellocyte effector cells. These results suggest that JAK/STAT signaling in muscles participates in a systemic immune defense against wasp infection.
JAK/STAT信号通路在果蝇细胞免疫反应中的作用尚未完全明确。在此，我们发现寄生蜂感染可激活果蝇幼虫体壁肌肉中的JAK/STAT信号通路，这是由循环血细胞分泌的细胞因子Upd2和Upd3所触发的。缺失upd2或upd3基因（而非相关的os基因，即upd1）会降低细胞免疫反应，并且抑制肌肉细胞中的JAK/STAT信号通路会减少对黄蜂卵的包囊作用以及循环中的片状血细胞效应细胞的数量。这些结果表明，肌肉中的JAK/STAT信号通路参与了针对黄蜂感染的全身性免疫防御。
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