Sartim Marco A, Sampaio Suely V
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Avenida do Café, s/n, Ribeirão Preto, SP CEP 14040-903 Brazil.
J Venom Anim Toxins Incl Trop Dis. 2015 Sep 24;21:35. doi: 10.1186/s40409-015-0038-3. eCollection 2015.
Snake venom galactoside-binding lectins (SVgalLs) comprise a class of toxins capable of recognizing and interacting with terminal galactoside residues of glycans. In the past 35 years, since the first report on the purification of thrombolectin from Bothrops atrox snake venom, several SVgalLs from Viperidae and Elapidae snake families have been described, as has progressive improvement in the investigation of structural/functional aspects of these lectins. Moreover, the advances of techniques applied in protein-carbohydrate recognition have provided important approaches in order to screen for possible biological targets. The present review describes the efforts over the past 35 years to elucidate SVgalLs, highlighting their structure and carbohydrate recognition function involved in envenomation pathophysiology and potential biomedical applications.
蛇毒半乳糖苷结合凝集素（SVgalLs）是一类能够识别聚糖末端半乳糖苷残基并与之相互作用的毒素。在过去35年里，自首次报道从矛头蝮蛇毒中纯化出血栓凝集素以来，已经描述了几种来自蝰蛇科和眼镜蛇科蛇类的SVgalLs，并且对这些凝集素结构/功能方面的研究也在不断进步。此外，蛋白质-碳水化合物识别技术的进展为筛选可能的生物靶点提供了重要方法。本综述描述了过去35年里为阐明SVgalLs所做的努力，重点介绍了它们的结构以及在蛇毒中毒病理生理学和潜在生物医学应用中涉及的碳水化合物识别功能
