Reimann Raissa S, Barreto Breno O C, Romano Filippo, Medeiros Jade G C, Camargo Bruna C, da Silva Josiel N, Soares Ana Luiza B, de Souza Mateus Farias, Macedo Jamile Mariano, Kayano Anderson M, Zuliani Juliana P, de Oliveira Ana Novo, da Silva Saulo L, Diniz-Sousa Rafaela, Soares Andreimar M
Curso de Medicina, Centro Universitário São Lucas, SÃO LUCAS PVH, Porto Velho-RO, Brazil.
Fundação Oswaldo Cruz, FIOCRUZ, Fiocruz Rondônia, Porto Velho-RO, Brazil.
Curr Med Chem. 2025;32(14):2683-2710. doi: 10.2174/0109298673290981240416070550.
The pursuit of novel treatment alternatives to address the accumulated resistance to antimicrobials over the years has prompted the scientific community to explore biodiversity, particularly animal venom, as a potential source of new antimicrobial drugs. Snake venoms, with their complex mixtures of components, are particularly promising targets for investigation in this regard. The search for novel molecules exhibiting antimicrobial activity against multidrug-resistant strains is of paramount importance for public health and numerous research groups worldwide. High expectations within the healthcare field are supported by the scientific literature, which highlights the potential development of innovative drugs through and application, depending on dose titration. Snake venoms and their molecules and peptides offer exponential possibilities for biotechnological applications as antimicrobial agents. However, many uncertainties and unexplored avenues remain, presenting opportunities for discoveries and research.
多年来，由于抗菌药物耐药性不断累积，人们一直在寻求新的治疗方法，这促使科学界探索生物多样性，尤其是动物毒液，将其作为新型抗菌药物的潜在来源。蛇毒具有复杂的成分混合物，在这方面是特别有前景的研究目标。寻找对多重耐药菌株具有抗菌活性的新型分子对全球公共卫生和众多研究团队而言至关重要。科学文献支持了医疗保健领域的高度期望，这些文献强调了根据剂量滴定通过[具体方式1]和[具体方式2]应用来开发创新药物的潜力。蛇毒及其分子和肽作为抗菌剂在生物技术应用方面提供了巨大的可能性。然而，许多不确定性和未探索的途径仍然存在，这为发现和研究提供了机会。
