Wade Benjamin S C, Valcour Victor G, Wendelken-Riegelhaupt Lauren, Esmaeili-Firidouni Pardis, Joshi Shantanu H, Wang Yalin, Thompson Paul M
Imaging Genetics Center, University of Southern California, Los Angeles, CA, USA.
Memory and Aging Center, Dept. of Neurology, University of California, San Francisco, CA, USA.
Proc IEEE Int Symp Biomed Imaging. 2015 Apr;2015:971-975. doi: 10.1109/ISBI.2015.7164033.
Over 50% of HIV+ individuals exhibit neurocognitive impairment and subcortical atrophy, but the pattern of brain abnormalities associated with HIV is still poorly understood. Using parametric surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 HIV+ participants and 31 uninfected controls. The thalamus, corpus striatum, hippocampus, amygdala, brainstem, callosum and ventricles were segmented from brain MRIs. To investigate subcortical shape, we analyzed the Jacobian determinant (JD) and radial distances (RD) for structure surfaces. We also investigated effects of nadir CD4+ T-cell counts, viral load, and illness duration on subcortical morphology. Our results characterize subcortical morphometry in older HIV+ people, where participants showed significant volumetric enlargements in the thalamus, left pallidum and the ventricles while showing a reduction in the callosum. Further, RD maps revealed atrophy of the left thalamus and expansion of the brainstem in HIV. RD and JD maps of the right pallidum identified tissue expansion associated with illness duration while the left pallidum showed anterior atrophy and posterior expansion associated with viral load.
超过50%的HIV阳性个体表现出神经认知障碍和皮质下萎缩，但与HIV相关的脑部异常模式仍知之甚少。我们使用基于参数曲面的形状分析方法，绘制了63名HIV阳性参与者和31名未感染对照者的皮质下形态测量三维轮廓图。从脑部磁共振成像（MRI）中分割出丘脑、纹状体、海马体、杏仁核、脑干、胼胝体和脑室。为了研究皮质下形状，我们分析了结构表面的雅可比行列式（JD）和径向距离（RD）。我们还研究了最低CD4 + T细胞计数、病毒载量和病程对皮质下形态的影响。我们的研究结果描述了老年HIV阳性人群的皮质下形态测量特征，这些参与者的丘脑、左侧苍白球和脑室出现显著体积增大，而胼胝体体积减小。此外，RD图显示HIV患者左侧丘脑萎缩和脑干扩张。右侧苍白球的RD和JD图显示与病程相关的组织扩张，而左侧苍白球显示与病毒载量相关的前部萎缩和后部扩张。
