高非对映选择性和对映选择性的 NHC 催化烯醛和靛红的 [3+2] 环加成反应。
Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins.
机构信息
Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Chem Commun (Camb). 2011 Sep 28;47(36):10136-8. doi: 10.1039/c1cc13860j. Epub 2011 Aug 9.
PMID:21829804
Abstract
The chiral N-heterocyclic carbene bearing a proximal hydroxy group derived from L-pyroglutamic acid was found to be an efficient catalyst for the [3+2] annulation of enals and isatins to give the corresponding spirocyclic oxindolo-γ-butyrolactones in good yield with good diastereo- and enantioselectivities.
摘要
手性 N-杂环卡宾带有一个来自 L-焦谷氨酸的邻近羟基，被发现是一种有效的催化剂，用于烯醛和色满酮的 [3+2] 环加成反应，以高产率和良好的非对映选择性和对映选择性得到相应的螺环氧化吲哚-γ-丁内酯。
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