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固态辐照下氨基酸的化学稳定性：亮氨酸、异亮氨酸和缬氨酸的案例研究。

Amino acids chemical stability submitted to solid state irradiation: the case study of leucine, isoleucine and valine.

作者信息

Cherubini Cristina, Ursini Ornella

机构信息

Institute of Chemical Methodologies-National Research Council of Italy, Via Salaria Km. 29,300, 00015 Monterotondo, RM Italy.

出版信息

Springerplus. 2015 Sep 22;4:541. doi: 10.1186/s40064-015-1332-9. eCollection 2015.

DOI:10.1186/s40064-015-1332-9
PMID:26413447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4579194/
Abstract

A solid state radiolysis was conducted to examine the reactivity of amino acids towards high energy dose of gamma radiations. The presence of amino acids in the bulk of meteorites has raised the question of "if" and eventually "how" they could have been important in the development of life on Earth. The presence of radioactive elements in Solar System bodies could have played a crucial role in amino acids survival and in the formation of different organic molecules. The radioactive elements produced a total radiation dose of 14 MGy during the life of Solar System (4.6 × 10(9) years). The aim of this study is to investigate the amino acids capacity to survive at a dose of γ-irradiation equivalent to 1.05 × 10(9) years of Solar System life. In particular, we examined the behavior of three essential amino acids (leucine, isoleucine and valine) submitted to a total dose of 3.2 MGy. We choose to irradiate l-enantiomers to analyze the behavior of a single enantiomer to radiations. We identified the radiation products formed in solid state radiolysis by mass spectrometric analysis and we were able to enlighten some common reactions. These reactions are particularly important to rationalize the formation of prebiotic molecules. Moreover, we studied the radioracemization process, the formation of d-enantiomer promoted by γ-irradiation.

摘要

进行了固态辐射分解实验，以研究氨基酸对高剂量伽马辐射的反应活性。陨石主体中氨基酸的存在引发了这样一个问题：它们“是否”以及最终“如何”在地球生命的发展过程中发挥重要作用。太阳系天体中放射性元素的存在可能在氨基酸的存活以及不同有机分子的形成过程中起到了关键作用。在太阳系存在的46亿年时间里，放射性元素产生的总辐射剂量为14兆戈瑞。本研究的目的是调查氨基酸在相当于太阳系10.5亿年寿命的伽马辐射剂量下的存活能力。具体而言，我们研究了三种必需氨基酸（亮氨酸、异亮氨酸和缬氨酸）在总剂量为3.2兆戈瑞照射下的行为。我们选择辐照左旋对映体，以分析单一异构体对辐射的反应。通过质谱分析，我们确定了固态辐射分解过程中形成的辐射产物，并能够阐明一些常见反应。这些反应对于解释益生元分子的形成尤为重要。此外，我们还研究了辐射外消旋过程，即伽马辐射促进右旋对映体的形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/982fed8de5cd/40064_2015_1332_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/f33b0fd11702/40064_2015_1332_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/6baa67e73422/40064_2015_1332_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/a706c5696c4e/40064_2015_1332_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/a7092798f505/40064_2015_1332_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/f232cc09855d/40064_2015_1332_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/87997a79ebdc/40064_2015_1332_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/26f3865515de/40064_2015_1332_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/221687c5afda/40064_2015_1332_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/982fed8de5cd/40064_2015_1332_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/f33b0fd11702/40064_2015_1332_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/6baa67e73422/40064_2015_1332_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/a706c5696c4e/40064_2015_1332_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/a7092798f505/40064_2015_1332_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/f232cc09855d/40064_2015_1332_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/87997a79ebdc/40064_2015_1332_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/26f3865515de/40064_2015_1332_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/221687c5afda/40064_2015_1332_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/4579194/982fed8de5cd/40064_2015_1332_Fig9_HTML.jpg

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