口服葡萄糖耐量试验对血浆淀粉样蛋白水平的调节作用：一种新型生物标志物。
Oral glucose tolerance testing to modulate plasma amyloid levels: A novel biomarker.
作者信息
Oh Esther S, Marano Christopher M, Leoutsakos Jeannie-Marie, Lee Rebecca W, Rissman Robert A, Smith Gwenn S, Craft Suzanne, Lyketsos Constantine G
机构信息
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Alzheimers Dement (Amst). 2015 Sep;1(3):311-315. doi: 10.1016/j.dadm.2015.06.002.
INTRODUCTION
Plasma levels of amyloid-beta (Aβ) do not correlate well with different stages of Alzheimer's disease (AD) in cross-sectional studies. Measuring the changes in Aβ plasma levels with an acute intervention may be more sensitive to distinguishing individuals in earlier stages of AD (mild cognitive impairment; MCI) from normal controls.
METHODS
57 participants (18 with AD/MCI and 39 cognitively normal controls) underwent oral glucose tolerance testing (OGTT). Blood samples were obtained over a 2 hour time period. Changes in plasma Aβ40 and42 levels were measured from either baseline or 5 minutes to the 10 minute time point.
RESULTS
Compared to normal controls, subjects with AD/MCI had significantly less change (Δ) in plasma levels for both Aβ40(-3.13(40.93)pg/ml vs. 41.34(57.16)pg/ml;p=0.002) and Aβ42(-0.15(3.77)pg/ml vs. 5.64(10.65)pg/ml; p=0.004).
DISCUSSION
OGTT combined with measures of plasma Aβ40 and 42 is potentially useful in distinguishing aging individuals who are in different stages of AD.
引言
在横断面研究中，血浆β淀粉样蛋白（Aβ）水平与阿尔茨海默病（AD）的不同阶段相关性不佳。通过急性干预测量Aβ血浆水平的变化，对于区分AD早期阶段（轻度认知障碍；MCI）的个体与正常对照可能更为敏感。
方法
57名参与者（18名AD/MCI患者和39名认知正常对照）接受了口服葡萄糖耐量试验（OGTT）。在2小时内采集血样。从基线或5分钟至10分钟时间点测量血浆Aβ40和Aβ42水平的变化。
结果
与正常对照相比，AD/MCI患者的血浆Aβ40（-3.13（40.93）pg/ml对41.34（57.16）pg/ml；p=0.002）和Aβ42（-0.15（3.77）pg/ml对5.64（10.65）pg/ml；p=0.004）水平变化均显著较小。
讨论
OGTT联合血浆Aβ40和Aβ42测量可能有助于区分处于AD不同阶段的老年个体。
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