Manani G, Blasone R, Cirillo L, Vidoni G, La Rosa P, Franceschini L, Ricci R, Meroni M, Giron G P
G Anest Stomatol. 1989 Oct-Dec;18(4):7-17.
In a random trial on 40 patients undergoing extraction of the third lower molar 0.125 mg of triazolam were administered sublingually to 20 patients and placebo (lactulose solution 66.7%) to 20 patients. The sedative and amnesic effect rapidly appeared after triazolam while the anxiolytic effect was less pronounced. The recovery of psychomotor functions measured by standard psychomotor tests occurred rapidly and all patients were discharged after about 120 min from the end of the surgery. The judgment of the surgeon was positive as far as the anxiolytic and relaxing effects of triazolam was concerned. The patients treated with triazolam moreover appreciated the sedation induced by the drug. No cardiocirculatory complication was observed and the patients showed a considerable stability from the circulatory stand point. The results show that triazolam may represent a safe alternative to the use of other anxiolytic and sedative drugs in the minor surgery of the oral cavity.
在一项针对40例接受下颌第三磨牙拔除术患者的随机试验中,20例患者舌下含服0.125毫克三唑仑,另外20例患者服用安慰剂(66.7%乳果糖溶液)。三唑仑用药后镇静和遗忘作用迅速出现,而抗焦虑作用则不那么明显。通过标准精神运动测试测量的精神运动功能恢复迅速,所有患者在手术结束约120分钟后出院。就三唑仑的抗焦虑和放松作用而言,外科医生的评价是积极的。此外,接受三唑仑治疗的患者对药物引起的镇静效果表示满意。未观察到心血管循环并发症,从循环角度来看患者表现出相当的稳定性。结果表明,在口腔小手术中,三唑仑可能是使用其他抗焦虑和镇静药物的安全替代品。