[Morphologic studies of the reaction of the subcutaneous connective tissue in rats to implantation of porous ceramics].

In the authors carried out testing of the porous ceramics Al2O3 biocompatibility. Comminuted ceramics with an average graining 3.5 were inserted subcutaneously in suspension of physiological salt in rats. The animals were killed after 7, 15, 30, 60 and 180 days. Histologic testing of the skin together with the subcutis in the place of the ceramics' powder injection as well as testing of the internal organs was carried out. It was observed that already after 30 days the connective tissue reaction became stable and did not change until the end of the experiment. A connective tissular capsule 120-160 mu depth of collagenous fibre and some fibroblasts of the correct structure came into existence around the inserted ceramics' powder. In the course of the whole experiment neither macrophages nor great foreign bodies were observed. Accumulation of the ceramics' molecules and RES reactions were not observed in the internal organs. The tested ceramics in characterized by high tissular biocompatibility.