与结直肠癌转移相关的细胞信号通路及相关靶向药物。
Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents.
作者信息
Liu Xuan, Ji Qing, Fan Zhongze, Li Qi
机构信息
Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Interventional Cancer Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
出版信息
Future Oncol. 2015;11(21):2911-22. doi: 10.2217/fon.15.235. Epub 2015 Sep 28.
Colorectal cancer (CRC) is the third leading cancer worldwide and CRC-related death is mainly attributed to metastasis. Many cellular signaling pathways have been demonstrated to be aberrant in colorectal tumors, and some of them lead to the acquisition of malignant phenotypes. Therefore, the evaluation of signaling pathways implicated in CRC metastasis is urgent for further understanding of CRC progression and pharmacotherapy. This review focuses on several novel cellular signaling pathways associated with CRC metastasis, including Wnt/β-catenin, p53, COX, TGF-β/Smad, NF-κB, Notch, VEGF and JAKs/STAT3 signaling pathways. Targeted agents developed based on these pathways are also briefly discussed.
结直肠癌（CRC）是全球第三大常见癌症，与CRC相关的死亡主要归因于转移。许多细胞信号通路已被证明在结直肠肿瘤中异常，其中一些导致恶性表型的获得。因此，评估与CRC转移相关的信号通路对于进一步了解CRC进展和药物治疗至关重要。本综述重点关注与CRC转移相关的几种新型细胞信号通路，包括Wnt/β-连环蛋白、p53、COX、TGF-β/Smad、NF-κB、Notch、VEGF和JAKs/STAT3信号通路。还简要讨论了基于这些通路开发的靶向药物。
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