Xiang Liangcheng, Xiao Lihong, Gou Zhongping, Li Mei, Zhang Wei, Wang Haiping, Feng Ping
1 West China School of Public Health, Sichuan University , Chengdu, Sichuan, People's Republic of China .
2 Institute of Clinical Trials, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
Hum Gene Ther. 2015 Dec;26(12):841-9. doi: 10.1089/hum.2015.113. Epub 2015 Nov 5.
Gene therapy is becoming an important treatment modality for gravely ill patients, and today's medical students and postgraduates are both potential consumers and future providers of gene therapy. Therefore, their attitudes and concerns about gene therapy may directly influence its long-term development and implementation in the clinic. We performed a cross-sectional survey of medical students and postgraduates at West China Medical School of Sichuan University. A custom-designed questionnaire was distributed to 600 students, and 579 were valid (96.98% response). Most respondents (84.46%) indicated little prior knowledge about gene therapy. The proportion of respondents considering gene therapy as acceptable ranged from 63.73% for serious illness to 17.72% for genetic enhancement. Adverse side effects were the most frequent concern among respondents when asked to imagine that they would receive gene therapy to treat a severe brain-related illness. These results suggest that medical students in China consider gene therapy's acceptability to be rather low, and are most concerned about its adverse side effects.
基因治疗正成为重症患者的一种重要治疗方式，而如今的医学生和研究生既是基因治疗的潜在消费者，也是未来的提供者。因此，他们对基因治疗的态度和担忧可能会直接影响其在临床上的长期发展和应用。我们对四川大学华西医学院的医学生和研究生进行了一项横断面调查。向600名学生发放了一份定制问卷，其中579份有效（回复率为96.98%）。大多数受访者（84.46%）表示此前对基因治疗了解甚少。当被问及是否接受基因治疗时，认为基因治疗可接受的受访者比例从用于治疗重病的63.73%到用于基因增强的17.72%不等。当被要求想象自己将接受基因治疗来治疗严重脑部疾病时，不良反应是受访者最常担心的问题。这些结果表明，中国医学生认为基因治疗的可接受性相当低，并且最担心其不良反应。
