Timur Hakan, Tokmak Aytekin, Türkmen Gülenay G, Ali İnal Hasan, Uygur Dilek, Danışman Nuri
a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey .
b Ankara Training and Research Hospital , Ankara , Turkey , and.
J Matern Fetal Neonatal Med. 2016;29(15):2470-4. doi: 10.3109/14767058.2015.1089432. Epub 2015 Sep 28.
The aim of this study was to evaluate pregnancy outcomes in women with Ankylosing Spondylitis (AS), and the course of disease during pregnancy was also assessed.
This case-control study included 60 pregnant women who delivered in our clinic between March 2007 and 2015. Twenty of them diagnosed with AS formed the study group and 40 women were chosen as the control group. These patients were chosen and reviewed by their hospital records and were evaluated retrospectively in terms of their clinical characteristics, pregnancy complications and perinatal outcomes. The Ankylosing Spondylitis Disease Activity Score (ASDAS), a new composite index to assess disease activity in AS, was used in the assessment of the patients.
No adverse pregnancy outcome was noted in pregnant patients with AS. Mean age of AS patients was significantly higher than the controls (p = 0.037). The proportion of female fetuses was higher in pregnancies with AS compared to pregnant patients with healthy controls (p = 0.041). Fourteen (70%) of 20 patients displayed decrement in ASDAS during pregnancy. Course of AS was unaltered in 6 (30%) of 20 patients during pregnancy. Otherwise, the stage of the disease during pregnancy remained unchanged in 15 (75%) of cases as postpartum exacerbation was observed in 6 (30%). The reported symptoms of patients with AS during pregnancy were arthritis and uveitis.
Women with AS have a favorable pregnancy outcome, and pregnancy does not substantially aggravate disease activity or severity in these patients.
本研究旨在评估强直性脊柱炎（AS）女性患者的妊娠结局，并评估孕期疾病进程。
本病例对照研究纳入了2007年3月至2015年在我院分娩的60名孕妇。其中20名被诊断为AS的孕妇组成研究组，40名孕妇作为对照组。通过医院记录选取并回顾这些患者，对其临床特征、妊娠并发症和围产期结局进行回顾性评估。使用强直性脊柱炎疾病活动评分（ASDAS）这一评估AS疾病活动的新综合指标对患者进行评估。
AS孕妇未观察到不良妊娠结局。AS患者的平均年龄显著高于对照组（p = 0.037）。与健康对照孕妇相比，AS孕妇中女胎的比例更高（p = 0.041）。20名患者中有14名（70%）在孕期ASDAS下降。20名患者中有6名（30%）在孕期AS病程未改变。此外，15名（75%）患者孕期疾病阶段未变，6名（30%）患者产后病情加重。AS患者孕期报告的症状为关节炎和葡萄膜炎。
AS女性患者妊娠结局良好，妊娠不会显著加重这些患者的疾病活动或严重程度。
