妊娠对强直性脊柱炎的影响：一项病例对照研究。
Effect of pregnancy on ankylosing spondylitis: a case-control study.
机构信息
Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, Canada.
出版信息
J Rheumatol. 2011 Nov;38(11):2442-4. doi: 10.3899/jrheum.101174. Epub 2011 Aug 15.
OBJECTIVE
To evaluate the effect of pregnancy on ankylosing spondylitis (AS).
METHODS
Our study aimed to determine the severity of back pain and stiffness pre-, during, and postpartum in patients with AS and controls, and corresponding extraarticular symptoms.
RESULTS
Nineteen female patients with AS (35 pregnancies) and 33 controls (77 pregnancies) were studied. Improvement in pain was reported in 51% of AS patients, predominantly in the first trimester, with significant improvement in pain than stiffness. In both groups, pain worsened in later stages, likely secondary to biomechanical loading. Postpartum pain scores in AS returned to prepartum levels in general.
CONCLUSION
Pregnancy does not substantially aggravate disease activity or severity in AS.
目的
评估妊娠对强直性脊柱炎（AS）的影响。
方法
我们的研究旨在确定 AS 患者和对照组患者在妊娠前、妊娠中和产后背痛和僵硬的严重程度，以及相应的关节外症状。
结果
研究了 19 名女性 AS 患者（35 次妊娠）和 33 名对照组（77 次妊娠）。51%的 AS 患者报告疼痛改善，主要发生在妊娠早期，疼痛改善程度明显优于僵硬。在两组中，疼痛在后期加重，可能是生物力学负荷所致。AS 患者产后的疼痛评分通常会恢复到产前水平。
结论
妊娠不会显著加重 AS 的疾病活动或严重程度。
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