高尿酸血症、尿酸盐沉积及其与高血压的关联。

Hyperuricemia, urate deposition and the association with hypertension.

作者信息

Mancia G, Grassi G, Borghi C

机构信息

a a Department of Health Sciences , University of Milano-Bicocca , Milan , Italy.

b b Clinica Medica, Università Milano-Bicocca, Milan and Istituto di Ricerche a Carattere Scientifico IRCCS Multimedica , Sesto San Giovanni , Milan , Italy.

出版信息

Curr Med Res Opin. 2015;31 Suppl 2:15-9. doi: 10.1185/03007995.2015.1087981.

DOI:10.1185/03007995.2015.1087981

PMID:26414732

Abstract

Hyperuricemia is associated with hypertension, kidney disease, vascular and cardiovascular (CV) events. In experimental models, the inhibition of hepatic uricase induces hyperuricemia, hypertension and mild renal disease. Notably, the micro- and macrovascular changes observed in the experimental model of hyperuricemia resemble the histological changes of human hypertension. This paper presents and discusses the epidemiological correlation between high serum uric acid levels and hypertension, and reviews current evidence supporting the protective effects of the normalization of uric acid levels. This review is based on a PubMed/Embase database search for articles on hyperuricemia and its impact on cardiovascular and renal function.

摘要

高尿酸血症与高血压、肾脏疾病、血管及心血管（CV）事件相关。在实验模型中，抑制肝脏尿酸酶可诱发高尿酸血症、高血压及轻度肾脏疾病。值得注意的是，在高尿酸血症实验模型中观察到的微血管和大血管变化类似于人类高血压的组织学变化。本文介绍并讨论了高血清尿酸水平与高血压之间的流行病学相关性，并综述了支持尿酸水平正常化具有保护作用的现有证据。本综述基于对PubMed/Embase数据库中关于高尿酸血症及其对心血管和肾脏功能影响的文章的检索。