Perez-Ruiz F, Becker M A
a a Servicio de Reumatología, Hospital Universitario Cruces, Instituto de Investigación Biomédica BioCruces , Vizcaya , Spain.
b b Department of Medicine , The University of Chicago Pritzker School of Medicine , Chicago , Illinois , USA.
Curr Med Res Opin. 2015;31 Suppl 2:9-14. doi: 10.1185/03007995.2015.1087980.
Hyperuricemia and gout are independent risk factors associated with the development of hypertension, metabolic syndrome, vascular damage, and renal disease. Whether these risk factors are causally related to these important chronic co-morbidities remains uncertain, but inflammation may provide a mechanistic explanation. Hyperuricemia and gout negatively affect vascular function by exerting pro-oxidant effects and by decreasing nitric oxide bioavailability, thus inducing inflammation and endothelial dysfunction, which may promote hypertension, metabolic syndrome, and cardiovascular (CV) disease. This paper presents and discusses current understanding of the diverse influences promoting hyperuricemia and gout and the basis of acute and chronic hyperuricemia/gout-related inflammation. This review is based on a PubMed/Embase database search for articles on hyperuricemia and its impact on cardiovascular and renal function.
高尿酸血症和痛风是与高血压、代谢综合征、血管损伤及肾脏疾病发生相关的独立危险因素。这些危险因素与这些重要的慢性合并症之间是否存在因果关系尚不确定，但炎症可能提供一种机制性解释。高尿酸血症和痛风通过发挥促氧化作用以及降低一氧化氮生物利用度对血管功能产生负面影响，从而诱发炎症和内皮功能障碍，这可能会促进高血压、代谢综合征及心血管疾病的发生。本文介绍并讨论了目前对促进高尿酸血症和痛风的多种影响以及急性和慢性高尿酸血症/痛风相关炎症的基础的理解。本综述基于对PubMed/Embase数据库中关于高尿酸血症及其对心血管和肾功能影响的文章的检索。
