载血栓酶受体激动肽（TRAP）和蛋白 C γ-羧基谷氨酸（PC-Gla）的双腔蛋白纳米笼用于脓毒症治疗。
A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment.
机构信息
College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701, South Korea.
Department of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, CMRI, School of Medicine, Kyungpook National University, Daegu, 700-422, South Korea.
出版信息
Adv Mater. 2015 Nov;27(42):6637-43. doi: 10.1002/adma.201503093. Epub 2015 Sep 28.
New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.
新型蛋白纳米笼携带有两个功能蛋白，即蛋白 C 的 γ-羧基谷氨酸（PC-Gla）和凝血酶受体激动肽（TRAP），具有抗感染反应的作用。这些纳米颗粒减少了体内脓毒症引起的器官损伤和脓毒症死亡率。鉴于目前尚无治疗严重脓毒症的药物，这些结果表明新型纳米颗粒可用于治疗脓毒症。
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