Caspers J, Eickhoff S B, Amunts K, Antoch G, Zilles K
Department for Diagnostic and Interventional Radiology, Universitiy Hospital Düsseldorf, Germany.
Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine-University Düsseldorf, Germany.
Rofo. 2015 Oct;187(10):892-8. doi: 10.1055/s-0041-105062. Epub 2015 Sep 28.
To investigate the distribution of co-activation patterns of the recently identified ventral visual areas FG1 and FG2 of the posterior fusiform gyrus using the novel meta-analytic approach PaMiNI (Pattern Mining in NeuroImaging).
All neuroimaging experiments reporting activation foci within FG1 or FG2 were retrieved from the BrainMap database. The stereotaxic activation foci in standard reference space were analyzed with PaMiNI. Here, Gaussian mixture modeling was applied to the stereotaxic coordinates of all foci to identify the underlying brain regions of each dataset. Then, association analysis was performed to reveal frequent co-activations across the modeled brain regions.
Co-activation patterns of FG1 were mainly found within the visual system, i.e. in early visual areas, and were symmetrically distributed across both hemispheres. FG2 features several extra-visual co-activations, mainly to inferior frontal, premotor and parietal regions. Furthermore, the co-activations of FG2 showed clear lateralization to the left FG2.
FG1 shows characteristics of an intermediate visual area between the early ventral visual cortex and the category-specific higher-order areas. Co-activation patterns of FG2 indicate that FG2 is a higher-order visual area that probably corresponds to the posterior fusiform face area and partly the visual word-form area. Key points. Co-activation patterns of areas FG1 and FG2 were analyzed with PaMiNI. FG1 features mainly symmetric co-activations to areas of the visual system. FG2 shows several extra-visual co-activations, which are left-lateralized. FG1 corresponds to a hierarchically intermediate, FG2 to a higher-order visual area. The PaMiNI approach is extended to seed-specific mapping of co-activation patterns.
使用新型元分析方法PaMiNI（神经影像模式挖掘）研究后梭状回最近确定的腹侧视觉区域FG1和FG2的共激活模式分布。
从BrainMap数据库中检索所有报告FG1或FG2内激活焦点的神经影像实验。使用PaMiNI分析标准参考空间中的立体定向激活焦点。在此，对所有焦点的立体定向坐标应用高斯混合模型，以识别每个数据集的潜在脑区。然后，进行关联分析以揭示跨模型脑区的频繁共激活。
FG1的共激活模式主要出现在视觉系统内，即在早期视觉区域，并且在两个半球对称分布。FG2具有多种视觉外共激活，主要涉及额下回、运动前区和顶叶区域。此外，FG2的共激活在左侧FG2表现出明显的偏侧化。
FG1显示出早期腹侧视觉皮层和类别特异性高阶区域之间中间视觉区域的特征。FG2的共激活模式表明FG2是一个高阶视觉区域，可能对应于后梭状回面孔区和部分视觉词形区。要点。使用PaMiNI分析FG1和FG2区域的共激活模式。FG1的特征主要是与视觉系统区域的对称共激活。FG2显示出多种视觉外共激活，且偏向左半球。FG1对应于一个层次中间的视觉区域，FG2对应于一个高阶视觉区域。PaMiNI方法扩展到共激活模式的种子特异性映射。
