Ivanac-Janković Renata, Ćorić Marijana, Furić-Čunko Vesna, Lovičić Vesna, Bašić-Jukić Nikolina, Kes Petar
Acta Clin Croat. 2015 Jun;54(2):164-8.
Bone morphogenetic protein-7 (BMP-7) is expressed in all parts of the normal kidney parenchyma, being highest in the epithelium of proximal tubules. It protects kidney against acute and chronic injury, inflammation and fibrosis. Diabetic nephropathy is the leading cause of chronic kidney disease, and is characterized by decreased expression of BMP-7. The aim of our study was to analyze whether the expression of BMP-7 is significantly changed in advanced stages of human diabetic nephropathy. Immunohistochemical analysis of the expression of BMP-7 was performed on archival material of 30 patients that underwent renal biopsy and had confirmed diagnosis of diabetic nephropathy. Results showed that BMP-7 was differently expressed in the cytoplasm of epithelial cells of proximal tubules and podocytes among all stages of diabetic nephropathy. At early stages of diabetic nephropathy, BMP-7 was strongly positive in proximal tubules and podocytes, while low expression was recorded in the majority of samples at advanced stages. In conclusion, increased expression of BMP-7 at initial stages of diabetic nephropathy with subsequent decrease at advanced stage highlights the role of BMP-7 in the protection of kidney structure and function. Further investigations should be focused on disturbances of BMP-7 receptors and signaling pathways in patients with diabetic nephropathy.
骨形态发生蛋白-7（BMP-7）在正常肾实质的所有部位均有表达，在近端小管上皮中表达最高。它可保护肾脏免受急性和慢性损伤、炎症及纤维化的影响。糖尿病肾病是慢性肾脏病的主要病因，其特征是BMP-7表达降低。我们研究的目的是分析在人类糖尿病肾病晚期BMP-7的表达是否发生显著变化。对30例接受肾活检且确诊为糖尿病肾病患者的存档材料进行了BMP-7表达的免疫组织化学分析。结果显示，在糖尿病肾病的各个阶段，近端小管和足细胞上皮细胞胞质中BMP-7的表达存在差异。在糖尿病肾病早期，近端小管和足细胞中BMP-7呈强阳性，而在晚期大多数样本中表达较低。总之，糖尿病肾病初期BMP-7表达增加，随后在晚期降低，这突出了BMP-7在保护肾脏结构和功能中的作用。进一步的研究应聚焦于糖尿病肾病患者中BMP-7受体和信号通路的紊乱。
