Fu Yu, Li Jinming
National Center for Clinical Laboratories, Beijing Hospital, Beijing 100029, China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China; Departments of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
National Center for Clinical Laboratories, Beijing Hospital, Beijing 100029, China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.
Virus Res. 2016 Jan 4;211:9-16. doi: 10.1016/j.virusres.2015.08.022. Epub 2015 Sep 28.
Our objective here is to review the novel delivery platform based on Bacteriophage MS2 virus-like particles (VLPs), including introduction to their structure, their potential as a delivery platform, and their expected use in medicine and other fields. Bacteriophage MS2 VLPs are nanoparticles devoid of viral genetic material and can self-assemble from the coat protein into an icosahedral capsid. As a novel delivery platform, they possess numerous features that make them suitable and attractive for targeted delivery of RNAs or DNAs, epitope peptides, and drugs within the protein capsid. In short, as a novel delivery platform, MS2 VLPs are suitable for delivery of targeted agents and hold promise for use in diagnostics, vaccines, and therapeutic modalities.
我们在此的目标是综述基于噬菌体MS2病毒样颗粒（VLP）的新型递送平台，包括介绍其结构、作为递送平台的潜力以及它们在医学和其他领域的预期用途。噬菌体MS2 VLP是不含病毒遗传物质的纳米颗粒，可由衣壳蛋白自组装成二十面体衣壳。作为一种新型递送平台，它们具有众多特性，使其适合并吸引用于在蛋白衣壳内靶向递送RNA或DNA、表位肽和药物。简而言之，作为一种新型递送平台，MS2 VLP适合递送靶向制剂，并有望用于诊断、疫苗和治疗方式。
